Bioavailability and Fate of Sediment-Associated Progesterone in Aquatic Systems.
Environ Sci Technol
; 50(7): 4027-36, 2016 Apr 05.
Article
en En
| MEDLINE
| ID: mdl-26938708
ABSTRACT
The environmental fate and bioavailability of progesterone, a steroid hormone known to cause endocrine-disrupting effects in aquatic organisms, is of growing concern due to its occurrence in the environment in water and sediment influenced by wastewater treatment plant and paper mill effluents, as well as livestock production. The objective of this study was to evaluate the fate of progesterone in two natural sediments and the corresponding alteration of gene expression in three steroid-responsive genes; vitellogenin, androgen receptor and estrogen receptor alpha. When exposed to progesterone-spiked sand, fathead minnows (Pimephales promelas) exhibited significant reductions in the expression of vitellogenin and androgen receptor expression. In contrast, fish exposed to progesterone associated with the silty loam sediment did not show a biological response at 7 days and only realized a significant reduction in vitellogenin. In both sediments, progesterone degradation resulted in the production of androgens including androsteinedione, testosterone, and androstadienedione, as well as the antiestrogen, testolactone. Differences in compound fate resulted in organism exposure to different suites of metabolites either in water or associated with the sediment. Results from this study suggest that environmental progestagens will lead to defeminization at environmentally relevant concentrations, and that exposure is influenced by sediment properties.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Progesterona
/
Cyprinidae
/
Monitoreo del Ambiente
/
Sedimentos Geológicos
/
Organismos Acuáticos
Tipo de estudio:
Risk_factors_studies
Límite:
Animals
Idioma:
En
Revista:
Environ Sci Technol
Año:
2016
Tipo del documento:
Article
País de afiliación:
Estados Unidos