Deposition of C-terminally truncated Aß species Aß37 and Aß39 in Alzheimer's disease and transgenic mouse models.
Acta Neuropathol Commun
; 4: 24, 2016 Mar 08.
Article
en En
| MEDLINE
| ID: mdl-26955942
ABSTRACT
In Alzheimer's disease (AD) a variety of amyloid ß-peptides (Aß) are deposited in the form of extracellular diffuse and neuritic plaques (NP), as well as within the vasculature. The generation of Aß from its precursor, the amyloid precursor protein (APP), is a highly complex procedure that involves subsequent proteolysis of APP by ß- and γ-secretases. Brain accumulation of Aß due to impaired Aß degradation and/or altered ratios between the different Aß species produced is believed to play a pivotal role in AD pathogenesis. While the presence of Aß40 and Aß42 in vascular and parenchymal amyloid have been subject of extensive studies, the deposition of carboxyterminal truncated Aß peptides in AD has not received comparable attention. In the current study, we for the first time demonstrate the immunohistochemical localization of Aß37 and Aß39 in human sporadic AD (SAD). Our study further included the analysis of familial AD (FAD) cases carrying the APP mutations KM670/671NL, E693G and I716F, as well as a case of the PSEN1 ΔExon9 mutation. Aß37 and Aß39 were found to be widely distributed within the vasculature in the brains of the majority of studied SAD and FAD cases, the latter also presenting considerable amounts of Aß37 containing NPs. In addition, both peptides were found to be present in extracellular plaques but only scarce within the vasculature in brains of a variety of transgenic AD mouse models. Taken together, our study indicates the importance of C-terminally truncated Aß in sporadic and familial AD and raises questions about how these species are generated and regulated.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Encéfalo
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Regulación de la Expresión Génica
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Péptidos beta-Amiloides
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Enfermedad de Alzheimer
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Mutación
Tipo de estudio:
Prognostic_studies
Límite:
Aged
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Aged80
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Animals
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Acta Neuropathol Commun
Año:
2016
Tipo del documento:
Article
País de afiliación:
Alemania