Molecular Genetic Profiling of Adolescent Glassy Cell Carcinoma of the Cervix Reveals Targetable EGFR Amplification with Potential Therapeutic Implications.
J Adolesc Young Adult Oncol
; 5(3): 297-302, 2016 09.
Article
en En
| MEDLINE
| ID: mdl-26974246
ABSTRACT
Glassy cell carcinoma of the cervix (GCCC) is a very rare and aggressive form of cervical cancer. An adolescent female with advanced metastatic disease was enrolled in our genomic profiling research protocol. We identified high-level amplification of epidermal growth factor receptor (EGFR) and Yes-associated protein-1 (YAP1), which led to the addition of EGFR inhibitors to the chemotherapy regimen. Here, we report the first genetically profiled case of GCCC with potential therapeutic implications.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Neoplasias del Cuello Uterino
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Receptores ErbB
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Biología Molecular
Tipo de estudio:
Guideline
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Prognostic_studies
Límite:
Adolescent
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Female
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Humans
Idioma:
En
Revista:
J Adolesc Young Adult Oncol
Año:
2016
Tipo del documento:
Article