[New perspective on the role of WNK1 and WNK4 in the regulation of NaCl reabsorption and K(+) secretion by the distal nephron]. / Réabsorption du sel et sécrétion du potassium par le néphron distal - Vision nouvelle du rôle régulateur des kinases de la famille WNK.
Med Sci (Paris)
; 32(3): 274-80, 2016 Mar.
Article
en Fr
| MEDLINE
| ID: mdl-27011246
ABSTRACT
The study of Familial Hyperkalemic Hypertension (FHHt), a rare monogenic disease, allowed remarkable advances in the understanding of the mechanisms of regulation of NaCl reabsorption by the distal nephron. FHHt results from mutations in the genes encoding WNK1 and WNK4, two serine-threonine kinases of the WNK (With No lysine [K]) family. The clinical manifestations of FHHt are due, among others, to an increased activity of the Na(+)-Cl(-) cotransporter NCC. Several groups therefore tried to understand how WNK1 and WNK4 could regulate NCC. However, the data were often contradictory. Two of our recent studies allowed to partially explain these controversies and to propose a new model for the regulation of NCC by the WNKs.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Potasio
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Cloruro de Sodio
/
Antígenos de Histocompatibilidad Menor
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Proteínas Serina-Treonina Quinasas
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Péptidos y Proteínas de Señalización Intracelular
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Nefronas
Límite:
Animals
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Humans
Idioma:
Fr
Revista:
Med Sci (Paris)
Asunto de la revista:
MEDICINA
Año:
2016
Tipo del documento:
Article
País de afiliación:
Francia