The influence of steatosis on the short- and long-term results of resection of liver metastases from colorectal carcinoma.
HPB (Oxford)
; 18(4): 389-96, 2016 Apr.
Article
en En
| MEDLINE
| ID: mdl-27037210
ABSTRACT
UNLABELLED We aimed to establish whether the presence of hepatic steatosis influences outcome after resection of colorectal liver metastases (CLM). PATIENTS AND METHODS:
Patients operated between 1990 and 2014 were divided into four groups based on the degree of hepatic steatosis. The association between hepatic steatosis and outcome was analyzed, using a multivariate and a propensity score case-match analysis.RESULTS:
No significant differences were observed between patients with and without steatosis in either mortality or morbidity in the complete series or after matching (3.2% vs. 3.5%/p = 0.845) (32.3% vs 31.4%/p = 0.802). Five-year survival in patients with and without steatosis were 56.5% and 46.5% respectively (p = 0.046). The steatosis had a significant protective effect in the univariate analysis (HR (95% CI) = 0.78 (0.62-0.99) p = 0.048), and was close to significance in the multivariate analysis (HR (95%) = 0.81 (0.63-1.03) p = 0.089). No significant differences were seen with regard to liver recurrence.CONCLUSIONS:
The presence of steatosis does not predict short-outcome after resection of CLM, but appears to be a favorable prognostic factor for survival. This protective effect does not depend on a decrease in liver recurrence.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Carcinoma
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Neoplasias Colorrectales
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Hígado Graso
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Metastasectomía
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Hepatectomía
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Neoplasias Hepáticas
Tipo de estudio:
Diagnostic_studies
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Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Aged
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Female
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Humans
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Male
Idioma:
En
Revista:
HPB (Oxford)
Asunto de la revista:
GASTROENTEROLOGIA
Año:
2016
Tipo del documento:
Article