Valsartan attenuates intimal hyperplasia in balloon-injured rat aortic arteries through modulating the angiotensin-converting enzyme 2-angiotensin-(1-7)-Mas receptor axis.
Arch Biochem Biophys
; 598: 11-7, 2016 05 15.
Article
en En
| MEDLINE
| ID: mdl-27050934
ABSTRACT
The role of the Mas receptor in the activity of valsartan against intimal hyperplasia is unclear. Herein, we investigated the role of the angiotensin-converting enzyme 2 (ACE2)-angiotensin-(1-7)-Mas receptor axis on the activity of valsartan against intimal hyperplasiain balloon-injured rat aortic arteries. Wistar rats were randomized equally into the sham control group, injured group, and injured plus valsartan (20 mg/kg/d)-treated group. Valsartan significantly attenuated the vascular smooth muscle cell proliferation and intimal and medial thickening on days 14 and 28 after injury. The angiotensin-(1-7) levels as well as ACE2 and Mas receptor mRNA/protein expression were significantly decreased in the injured rats, compared to the uninjured rats; meanwhile, the angiotensin II level as well as the ACE and AT1 receptor mRNA/protein expression were increased (all P < 0.05 or < 0.01). Additionally, the p-ERK protein expression was increased (P < 0.01). Treatment with valsartan significantly increased the angiotensin-(1-7) levels as well as ACE2 and Mas receptor mRNA/protein expression but decreased the angiotensin II level, ACE and AT1 receptor mRNA/protein expression, as well as the p-ERK protein expression, compared to the injured group (all P < 0.05 or < 0.01). These results suggest that valsartan attenuates neointimal hyperplasiain balloon-injured rat aortic arteries through activation of the ACE2-angiotensin-(1-7)-Mas axis as well as inhibition of the ACE-angiotensin II-AT1 and p-ERK pathways.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Aorta
/
Regulación Enzimológica de la Expresión Génica
/
Proteínas Proto-Oncogénicas
/
Túnica Íntima
/
Peptidil-Dipeptidasa A
/
Sistema de Señalización de MAP Quinasas
/
Receptores Acoplados a Proteínas G
/
Valsartán
Límite:
Animals
Idioma:
En
Revista:
Arch Biochem Biophys
Año:
2016
Tipo del documento:
Article
País de afiliación:
China