A Single Amino Acid Substitution Prevents Recognition of a Dominant Human Aquaporin-4 Determinant in the Context of HLA-DRB1*03:01 by a Murine TCR.

Arellano, Benjamine; Hussain, Rehana; Miller-Little, William A; Herndon, Emily; Lambracht-Washington, Doris; Eagar, Todd N; Lewis, Robert; Healey, Don; Vernino, Steven; Greenberg, Benjamin M; Stüve, Olaf

Arellano, Benjamine; Hussain, Rehana; Miller-Little, William A; Herndon, Emily; Lambracht-Washington, Doris; Eagar, Todd N; Lewis, Robert; Healey, Don; Vernino, Steven; Greenberg, Benjamin M; Stüve, Olaf.

Afiliación

Arellano B; Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, United States of America.
Hussain R; Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, United States of America.
Miller-Little WA; Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, United States of America.
Herndon E; Department of Pathology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, United States of America.
Lambracht-Washington D; Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, United States of America.
Eagar TN; Histocompatibility and Transplant Immunology, Department of Pathology and Genomic Medicine, The Methodist Hospital Physician Organization, Houston, TX, United States of America.
Lewis R; Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, United States of America.
Healey D; Opexa Therapeutics, The Woodlands, TX, United States of America.
Vernino S; Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, United States of America.
Greenberg BM; Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, United States of America.
Stüve O; Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, United States of America.

PLoS One ; 11(4): e0152720, 2016.

Article en En | MEDLINE | ID: mdl-27054574

Asunto(s)

Acuaporina 4/genética; Acuaporina 4/inmunología; Cadenas HLA-DRB1/genética; Neuromielitis Óptica/inmunología; Receptores de Antígenos de Linfocitos T/metabolismo; Secuencia de Aminoácidos; Sustitución de Aminoácidos; Animales; Acuaporina 4/metabolismo; Linfocitos T CD4-Positivos/inmunología; Diferenciación Celular; Proliferación Celular; Modelos Animales de Enfermedad; Encefalomielitis Autoinmune Experimental/inmunología; Femenino; Cadenas HLA-DRB1/metabolismo; Humanos; Ratones Endogámicos C57BL; Ratones Transgénicos; Datos de Secuencia Molecular; Neuromielitis Óptica/genética; Vacunación

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Receptores de Antígenos de Linfocitos T / Neuromielitis Óptica / Acuaporina 4 / Cadenas HLA-DRB1 Límite: Animals / Female / Humans Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos

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