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Synthesis of a stable and orally bioavailable englerin analogue.
Fash, David M; Peer, Cody J; Li, Zhenwu; Talisman, Ian J; Hayavi, Sima; Sulzmaier, Florian J; Ramos, Joe W; Sourbier, Carole; Neckers, Leonard; Figg, W Douglas; Beutler, John A; Chain, William J.
Afiliación
  • Fash DM; Department of Chemistry, University of Hawaii at Manoa, 2545 McCarthy Mall, Honolulu, HI 96822, United States.
  • Peer CJ; Genitourinary Malignancies Branch, National Cancer Institute, Frederick, MD 21702, United States.
  • Li Z; Department of Chemistry, University of Hawaii at Manoa, 2545 McCarthy Mall, Honolulu, HI 96822, United States.
  • Talisman IJ; Department of Chemistry, University of Hawaii at Manoa, 2545 McCarthy Mall, Honolulu, HI 96822, United States.
  • Hayavi S; Developmental Therapeutics Program, National Cancer Institute, Frederick, MD 21702, United States.
  • Sulzmaier FJ; The University of Hawaii Cancer Center, 701 Ilalo Street, Honolulu, HI 96813, United States.
  • Ramos JW; The University of Hawaii Cancer Center, 701 Ilalo Street, Honolulu, HI 96813, United States.
  • Sourbier C; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, United States.
  • Neckers L; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, United States.
  • Figg WD; Genitourinary Malignancies Branch, National Cancer Institute, Frederick, MD 21702, United States.
  • Beutler JA; Molecular Targets Laboratory, National Cancer Institute, Frederick, MD 21702, United States. Electronic address: beutlerj@mail.nih.gov.
  • Chain WJ; Department of Chemistry, University of Hawaii at Manoa, 2545 McCarthy Mall, Honolulu, HI 96822, United States; The University of Hawaii Cancer Center, 701 Ilalo Street, Honolulu, HI 96813, United States. Electronic address: wchain@udel.edu.
Bioorg Med Chem Lett ; 26(11): 2641-4, 2016 06 01.
Article en En | MEDLINE | ID: mdl-27107948
ABSTRACT
Synthesis of analogues of englerin A with a reduced propensity for hydrolysis of the glycolate moiety led to a compound which possessed the renal cancer cell selectivity of the parent and was orally bioavailable in mice.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Sesquiterpenos de Guayano / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Sesquiterpenos de Guayano / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos