What's on the Outside Matters: The Role of the Extracellular Polymeric Substance of Gram-negative Biofilms in Evading Host Immunity and as a Target for Therapeutic Intervention.

Gunn, John S; Bakaletz, Lauren O; Wozniak, Daniel J

Gunn, John S; Bakaletz, Lauren O; Wozniak, Daniel J.

Afiliación

Gunn JS; Department of Microbial Infection and Immunity, Ohio State University, Columbus, Ohio 43210; Center for Microbial Interface Biology, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio 43205.
Bakaletz LO; Department of Microbial Infection and Immunity, Ohio State University, Columbus, Ohio 43210; Center for Microbial Interface Biology, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio 43205; Departments of Pediatrics and Otolaryngology, The Research Institute at Nationwide Children's Hospital and Ohio State University, Columbus, Ohio 43210.
Wozniak DJ; Department of Microbial Infection and Immunity, Ohio State University, Columbus, Ohio 43210; Center for Microbial Interface Biology, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio 43205; Department of Microbiology, Ohio State University, Columbus, Ohio 43210. Electronic address: daniel.wozniak@osumc.edu.

J Biol Chem ; 291(24): 12538-12546, 2016 Jun 10.

Article en En | MEDLINE | ID: mdl-27129225

Asunto(s)

Infecciones Bacterianas/microbiología; Biopelículas/crecimiento & desarrollo; ADN Bacteriano/metabolismo; Matriz Extracelular/metabolismo; Bacterias Gramnegativas/fisiología; Polisacáridos Bacterianos/metabolismo; Antibacterianos/uso terapéutico; Infecciones Bacterianas/tratamiento farmacológico; Biopelículas/efectos de los fármacos; Bacterias Gramnegativas/efectos de los fármacos; Bacterias Gramnegativas/genética; Interacciones Huésped-Patógeno/efectos de los fármacos; Humanos; Evasión Inmune/efectos de los fármacos; Evasión Inmune/fisiología

Palabras clave

DNABII; Haemophilus influenzae; Pseudomonas aeruginosa; Salmonella; animal models; bacterial pathogenesis; biofilm; eDNA; extracellular matrix; matrix; neutrophil; phagocyte; pilin; polysaccharide

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Polisacáridos Bacterianos / Infecciones Bacterianas / ADN Bacteriano / Biopelículas / Matriz Extracelular / Bacterias Gramnegativas Límite: Humans Idioma: En Revista: J Biol Chem Año: 2016 Tipo del documento: Article

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