Proton Therapy for Pediatric Hodgkin Lymphoma.
Pediatr Blood Cancer
; 63(9): 1522-6, 2016 09.
Article
en En
| MEDLINE
| ID: mdl-27149120
ABSTRACT
BACKGROUND:
Compared to X-ray radiation therapy, proton therapy (PT) reduces the radiation dose to organs at risk, which is expected to translate into fewer second cancers and less cardiac morbidity decades after treatment. The Children's Oncology Group high-risk pediatric Hodgkin lymphoma (PHL) protocol, AHOD1331, allows the use of PT, yet limited data exist on the use of PT in PHL. PROCEDURE Between 2010 and 2014, 22 pediatric patients were treated with PT for PHL at our institution 7 intermediate-risk patients, 11 high-risk patients, and 4 relapsed patients. The patients' age ranged from 6 to 18 years old. Median follow-up was 36 months. All patients received chemotherapy before PT.RESULTS:
The 2-year and 3-year overall survival rates were both 94%, and the progression-free survival rate was 86%. Recurrences occurred in three high-risk patients one isolated in-field cervical lymph node and two in-field and out-of-field. All recurrences occurred within 5 months of completing PT. No PT-related grade 3 or higher acute or late complications were observed.CONCLUSION:
PT for PHL showed no short-term severe toxicity and yields similar short-term control to recently published large multi-institutional clinical trials.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Enfermedad de Hodgkin
/
Terapia de Protones
Tipo de estudio:
Guideline
Límite:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Pediatr Blood Cancer
Asunto de la revista:
HEMATOLOGIA
/
NEOPLASIAS
/
PEDIATRIA
Año:
2016
Tipo del documento:
Article