Phosphorylated heat shock protein 27 promotes lipid clearance in hepatic cells through interacting with STAT3 and activating autophagy.

Shen, Lei; Qi, Zhilin; Zhu, Yanyan; Song, Xiaomeng; Xuan, Chunxia; Ben, Peiling; Lan, Lei; Luo, Lan; Yin, Zhimin

Shen, Lei; Qi, Zhilin; Zhu, Yanyan; Song, Xiaomeng; Xuan, Chunxia; Ben, Peiling; Lan, Lei; Luo, Lan; Yin, Zhimin.

Afiliación

Shen L; Jiangsu Province Key Laboratory for Molecular Biotechnology, College of Life Science, Nanjing Normal University, No. 1 Wenyuan Road, Nanjing 210046, PR China.
Qi Z; Jiangsu Province Key Laboratory for Molecular Biotechnology, College of Life Science, Nanjing Normal University, No. 1 Wenyuan Road, Nanjing 210046, PR China; Department of Biochemistry, Wannan Medical College, Wuhu, Anhui, PR China.
Zhu Y; Jiangsu Province Key Laboratory for Molecular Biotechnology, College of Life Science, Nanjing Normal University, No. 1 Wenyuan Road, Nanjing 210046, PR China.
Song X; Jiangsu Province Key Laboratory for Molecular Biotechnology, College of Life Science, Nanjing Normal University, No. 1 Wenyuan Road, Nanjing 210046, PR China.
Xuan C; Jiangsu Province Key Laboratory for Molecular Biotechnology, College of Life Science, Nanjing Normal University, No. 1 Wenyuan Road, Nanjing 210046, PR China.
Ben P; Jiangsu Province Key Laboratory for Molecular Biotechnology, College of Life Science, Nanjing Normal University, No. 1 Wenyuan Road, Nanjing 210046, PR China.
Lan L; Jiangsu Province Key Laboratory for Molecular Biotechnology, College of Life Science, Nanjing Normal University, No. 1 Wenyuan Road, Nanjing 210046, PR China. Electronic address: lanlei1978@gmail.com.
Luo L; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing, Jiangsu, PR China. Electronic address: lanluo@nju.edu.cn.
Yin Z; Jiangsu Province Key Laboratory for Molecular Biotechnology, College of Life Science, Nanjing Normal University, No. 1 Wenyuan Road, Nanjing 210046, PR China. Electronic address: yinzhimin@njnu.edu.cn.

Cell Signal ; 28(8): 1086-98, 2016 08.

Article en En | MEDLINE | ID: mdl-27185187

Asunto(s)

Autofagia; Proteínas de Choque Térmico HSP27/metabolismo; Hepatocitos/citología; Hepatocitos/metabolismo; Lípidos/química; Factor de Transcripción STAT3/metabolismo; Animales; Anisoles; Autofagia/efectos de los fármacos; Línea Celular; Dieta Alta en Grasa; Factor 2 Eucariótico de Iniciación/metabolismo; Hígado Graso/metabolismo; Hígado Graso/patología; Proteínas de Choque Térmico/metabolismo; Hepatocitos/ultraestructura; Humanos; Isoxazoles; Hígado/metabolismo; Hígado/ultraestructura; Lisosomas/metabolismo; Masculino; Ratones; Ratones Endogámicos C57BL; Chaperonas Moleculares; Proteínas de Neoplasias/metabolismo; Palmitatos/farmacología; Fosforilación/efectos de los fármacos; Unión Proteica/efectos de los fármacos; eIF-2 Quinasa/metabolismo

Palabras clave

Autophagy; Hepatic steatosis; Hsp27 phosphorylation; STAT3

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Autofagia / Hepatocitos / Factor de Transcripción STAT3 / Proteínas de Choque Térmico HSP27 / Lípidos Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Cell Signal Año: 2016 Tipo del documento: Article

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