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Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma.
Saha, Supriya K; Gordan, John D; Kleinstiver, Benjamin P; Vu, Phuong; Najem, Mortada S; Yeo, Jia-Chi; Shi, Lei; Kato, Yasutaka; Levin, Rebecca S; Webber, James T; Damon, Leah J; Egan, Regina K; Greninger, Patricia; McDermott, Ultan; Garnett, Mathew J; Jenkins, Roger L; Rieger-Christ, Kimberly M; Sullivan, Travis B; Hezel, Aram F; Liss, Andrew S; Mizukami, Yusuke; Goyal, Lipika; Ferrone, Cristina R; Zhu, Andrew X; Joung, J Keith; Shokat, Kevan M; Benes, Cyril H; Bardeesy, Nabeel.
Afiliación
  • Saha SK; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.
  • Gordan JD; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California.
  • Kleinstiver BP; Molecular Pathology Unit, Center for Cancer Research, and Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, Massachusetts. Department of Pathology, Harvard Medical School, Boston, Massachusetts.
  • Vu P; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.
  • Najem MS; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.
  • Yeo JC; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.
  • Shi L; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.
  • Kato Y; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.
  • Levin RS; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, California.
  • Webber JT; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California.
  • Damon LJ; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.
  • Egan RK; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.
  • Greninger P; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.
  • McDermott U; Wellcome Trust Sanger Institute, Hinxton, UK.
  • Garnett MJ; Wellcome Trust Sanger Institute, Hinxton, UK.
  • Jenkins RL; Department of Transplantation, Lahey Hospital and Medical Center, Burlington, Massachusetts.
  • Rieger-Christ KM; Department of Translational Research, Lahey Hospital and Medical Center, Burlington, Massachusetts.
  • Sullivan TB; Department of Translational Research, Lahey Hospital and Medical Center, Burlington, Massachusetts.
  • Hezel AF; University of Rochester School of Medicine, Rochester, New York.
  • Liss AS; Department of Surgery and the Andrew L. Warshaw, MD, Institute for Pancreatic Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
  • Mizukami Y; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts. Center for Clinical and Biomedical Research, Sapporo Higashi Tokushukai Hospital, Sapporo, Hokkaido, Japan.
  • Goyal L; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.
  • Ferrone CR; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.
  • Zhu AX; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.
  • Joung JK; Molecular Pathology Unit, Center for Cancer Research, and Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, Massachusetts. Department of Pathology, Harvard Medical School, Boston, Massachusetts.
  • Shokat KM; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, California. Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, California.
  • Benes CH; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts. nelbardeesy@partners.org cbenes@mgh.harvard.edu.
  • Bardeesy N; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts. nelbardeesy@partners.org cbenes@mgh.harvard.edu.
Cancer Discov ; 6(7): 727-39, 2016 07.
Article en En | MEDLINE | ID: mdl-27231123
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Colangiocarcinoma / Familia-src Quinasas / Resistencia a Antineoplásicos / Dasatinib / Isocitrato Deshidrogenasa / Mutación Límite: Animals / Humans Idioma: En Revista: Cancer Discov Año: 2016 Tipo del documento: Article
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Colangiocarcinoma / Familia-src Quinasas / Resistencia a Antineoplásicos / Dasatinib / Isocitrato Deshidrogenasa / Mutación Límite: Animals / Humans Idioma: En Revista: Cancer Discov Año: 2016 Tipo del documento: Article