Hyperhomocysteinemia induced by excessive methionine intake promotes rupture of cerebral aneurysms in ovariectomized rats.

Korai, Masaaki; Kitazato, Keiko T; Tada, Yoshiteru; Miyamoto, Takeshi; Shimada, Kenji; Matsushita, Nobuhisa; Kanematsu, Yasuhisa; Satomi, Junichiro; Hashimoto, Tomoki; Nagahiro, Shinji

Korai, Masaaki; Kitazato, Keiko T; Tada, Yoshiteru; Miyamoto, Takeshi; Shimada, Kenji; Matsushita, Nobuhisa; Kanematsu, Yasuhisa; Satomi, Junichiro; Hashimoto, Tomoki; Nagahiro, Shinji.

Afiliación

Korai M; Department of Neurosurgery, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan. komakun@gmail.com.
Kitazato KT; Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA. komakun@gmail.com.
Tada Y; Department of Neurosurgery, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan.
Miyamoto T; Department of Neurosurgery, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan.
Shimada K; Department of Neurosurgery, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan.
Matsushita N; Department of Neurosurgery, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan.
Kanematsu Y; Department of Neurosurgery, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan.
Satomi J; Department of Neurosurgery, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan.
Hashimoto T; Department of Neurosurgery, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan.
Nagahiro S; Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA.

J Neuroinflammation ; 13(1): 165, 2016 06 27.

Article en En | MEDLINE | ID: mdl-27349749

Asunto(s)

Aneurisma Roto; Ácido Fólico/uso terapéutico; Hiperhomocisteinemia/inducido químicamente; Metionina/toxicidad; Complejo Vitamínico B/uso terapéutico; Aneurisma Roto/complicaciones; Aneurisma Roto/etiología; Aneurisma Roto/patología; Aneurisma Roto/prevención & control; Animales; Arterias/patología; Arterias/ultraestructura; Presión Sanguínea/efectos de los fármacos; Cisteína/sangre; Citocinas/genética; Citocinas/metabolismo; Modelos Animales de Enfermedad; Femenino; Hiperhomocisteinemia/fisiopatología; Metaloproteinasa 9 de la Matriz/metabolismo; NADPH Oxidasa 4; NADPH Oxidasas/metabolismo; Ovariectomía; Ratas; Ratas Sprague-Dawley; Hemorragia Subaracnoidea/etiología; Inhibidor Tisular de Metaloproteinasa-1/metabolismo; Inhibidor Tisular de Metaloproteinasa-2/metabolismo

Palabras clave

Anterior communicating artery; Cerebral aneurysm rupture; Folic acid; Hyperhomocysteinemia; Macrophage; Matrix metalloproteinase-9; Methionine; Tissue inhibitor of metalloproteinase-2

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Complejo Vitamínico B / Aneurisma Roto / Hiperhomocisteinemia / Ácido Fólico / Metionina Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Revista: J Neuroinflammation Asunto de la revista: NEUROLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Japón

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