Estimation of the frequency of inherited germline mutations by whole exome sequencing in ethyl nitrosourea-treated and untreated gpt delta mice.

Masumura, Kenichi; Toyoda-Hokaiwado, Naomi; Ukai, Akiko; Gondo, Yoichi; Honma, Masamitsu; Nohmi, Takehiko

Masumura, Kenichi; Toyoda-Hokaiwado, Naomi; Ukai, Akiko; Gondo, Yoichi; Honma, Masamitsu; Nohmi, Takehiko.

Afiliación

Masumura K; Division of Genetics and Mutagenesis, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo, 158-8501 Japan.
Toyoda-Hokaiwado N; Division of Genetics and Mutagenesis, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo, 158-8501 Japan.
Ukai A; Division of Genetics and Mutagenesis, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo, 158-8501 Japan.
Gondo Y; RIKEN BioResource Center, 3-1-1 Koyadai, Tsukuba, Ibaraki, 305-0074 Japan.
Honma M; Division of Genetics and Mutagenesis, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo, 158-8501 Japan.
Nohmi T; Division of Genetics and Mutagenesis, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo, 158-8501 Japan ; Biological Safety Research Center, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo, 158-8501 Japan.

Genes Environ ; 38: 10, 2016.

Article en En | MEDLINE | ID: mdl-27350829

Palabras clave

Exome sequencing; Germline mutation; Heritable mutation; Mutation spectrum; Transgenic rodent gene mutation assay

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Texto completo: 1 Bases de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Genes Environ Año: 2016 Tipo del documento: Article