Nanobodies® as inhaled biotherapeutics for lung diseases.
Pharmacol Ther
; 169: 47-56, 2017 01.
Article
en En
| MEDLINE
| ID: mdl-27373507
ABSTRACT
Local pulmonary delivery of biotherapeutics may offer advantages for the treatment of lung diseases. Delivery of the therapeutic entity directly to the lung has the potential for a rapid onset of action, reduced systemic exposure and the need for a lower dose, as well as needleless administration. However, formulation of a protein for inhaled delivery is challenging and requires proteins with favorable biophysical properties suitable to withstand the forces associated with formulation, delivery, and inhalation devices. Nanobodies are the smallest functional fragments derived from a naturally occurring heavy chain-only immunoglobulin. They are highly soluble, stable, and show biophysical characteristics that are particularly well suited for pulmonary delivery. This paper highlights a number of clinical and preclinical studies on antibodies delivered via the pulmonary route and describes the advantages of using Nanobodies for inhaled delivery to the lung. The latter is illustrated by the specific example of ALX-0171, a Nanobody in clinical development for the treatment of respiratory syncytial virus (RSV) infections.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Sistemas de Liberación de Medicamentos
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Anticuerpos de Dominio Único
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Enfermedades Pulmonares
Tipo de estudio:
Prognostic_studies
Límite:
Animals
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Humans
Idioma:
En
Revista:
Pharmacol Ther
Año:
2017
Tipo del documento:
Article