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Clinical response to liposomal doxorubicin and rituximab in HHV-8-associated multicentric Castleman's disease in an HIV-positive patient.
Osa, Morichika; Maeda, Takuya; Misawa, Kazuhisa; Imai, Kazuo; Fujikura, Yuji; Kawana, Akihiko.
Afiliación
  • Osa M; Division of Infectious Diseases and Pulmonary Medicine, Department of Internal Medicine, National Defense Medical College, Saitama, Japan.
  • Maeda T; Division of Infectious Diseases and Pulmonary Medicine, Department of Internal Medicine, National Defense Medical College, Saitama, Japan; Department of Microbiology, Saitama Medical University, Saitama, Japan. Electronic address: t_maeda@saitama-med.ac.jp.
  • Misawa K; Division of Infectious Diseases and Pulmonary Medicine, Department of Internal Medicine, National Defense Medical College, Saitama, Japan.
  • Imai K; Division of Infectious Diseases and Pulmonary Medicine, Department of Internal Medicine, National Defense Medical College, Saitama, Japan.
  • Fujikura Y; Division of Infectious Diseases and Pulmonary Medicine, Department of Internal Medicine, National Defense Medical College, Saitama, Japan.
  • Kawana A; Division of Infectious Diseases and Pulmonary Medicine, Department of Internal Medicine, National Defense Medical College, Saitama, Japan.
J Infect Chemother ; 22(12): 804-807, 2016 Dec.
Article en En | MEDLINE | ID: mdl-27373909
ABSTRACT
We report a patient with HIV-associated multicentric Castleman's disease who had recurrent human herpesvirus-8 viremia associated with intermittent febrile exanthema and lymphadenopathy. Although the patient relapsed after single-agent treatment with liposomal doxorubicin, weekly infusions of rituximab led to complete remission even though the reactivation of the Kaposi's sarcoma was unfortunately observed. Rituximab could not only eliminate the accumulation of HHV-8 load but also play a part in the modulation of dysregulated CD20-positive B cells in HIV-associated multicentric Castleman's disease.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Doxorrubicina / Infecciones por VIH / Enfermedad de Castleman / Herpesvirus Humano 8 / Rituximab Tipo de estudio: Risk_factors_studies Límite: Aged / Humans / Male Idioma: En Revista: J Infect Chemother Asunto de la revista: MICROBIOLOGIA / TERAPIA POR MEDICAMENTOS Año: 2016 Tipo del documento: Article País de afiliación: Japón
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Doxorrubicina / Infecciones por VIH / Enfermedad de Castleman / Herpesvirus Humano 8 / Rituximab Tipo de estudio: Risk_factors_studies Límite: Aged / Humans / Male Idioma: En Revista: J Infect Chemother Asunto de la revista: MICROBIOLOGIA / TERAPIA POR MEDICAMENTOS Año: 2016 Tipo del documento: Article País de afiliación: Japón