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Extended surface for membrane association in Zika virus NS1 structure.
Brown, W Clay; Akey, David L; Konwerski, Jamie R; Tarrasch, Jeffrey T; Skiniotis, Georgios; Kuhn, Richard J; Smith, Janet L.
Afiliación
  • Brown WC; Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, USA.
  • Akey DL; Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, USA.
  • Konwerski JR; Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, USA.
  • Tarrasch JT; Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, USA.
  • Skiniotis G; Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, USA.
  • Kuhn RJ; Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan, USA.
  • Smith JL; Department of Biological Sciences, Purdue University, West Lafayette, Indiana, USA.
Nat Struct Mol Biol ; 23(9): 865-7, 2016 09.
Article en En | MEDLINE | ID: mdl-27455458
ABSTRACT
The Zika virus, which has been implicated in an increase in neonatal microcephaly and Guillain-Barré syndrome, has spread rapidly through tropical regions of the world. The virulence protein NS1 functions in genome replication and host immune-system modulation. Here, we report the crystal structure of full-length Zika virus NS1, revealing an elongated hydrophobic surface for membrane association and a polar surface that varies substantially among flaviviruses.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Proteínas no Estructurales Virales Tipo de estudio: Risk_factors_studies Límite: Animals Idioma: En Revista: Nat Struct Mol Biol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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XML
PubMed Links
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Proteínas no Estructurales Virales Tipo de estudio: Risk_factors_studies Límite: Animals Idioma: En Revista: Nat Struct Mol Biol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos