Direct Regioselective [3 + 2]-Cyclization Reactions of Ambivalent Electrophilic/Nucleophilic ß-Chlorovinyl Dithianes: Access to Cyclopentene Derivatives.
Org Lett
; 18(19): 5086-5089, 2016 10 07.
Article
en En
| MEDLINE
| ID: mdl-27624691
ABSTRACT
The highly regioselective and operationally straightforward [3 + 2] cyclizations of ß-chlorovinyl dithianes with α,ß-unsaturated carbonyl compounds have been developed. This protocol provides direct access to highly functionalized cyclopentenes with perfect chemo- and regioselectivities under extremely mild reaction conditions. In particular, the unprecedented cyclization allows for the selective preparation of hydroxylated cyclopentenes.
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Bases de datos:
MEDLINE
Idioma:
En
Revista:
Org Lett
Asunto de la revista:
BIOQUIMICA
Año:
2016
Tipo del documento:
Article