Perinatal outcome in pregnant women with cancer: are there any effects of chemotherapy?
Eur J Cancer Care (Engl)
; 26(6)2017 Nov.
Article
en En
| MEDLINE
| ID: mdl-27642062
ABSTRACT
Cancer is the leading cause of death in women of reproductive age. During the last decades and especially in developed countries, the incidence of cancer is increasing dramatically, with an incidence of 1 in 1,000 pregnancies. This is mostly related to delay of pregnancy into the late reproductive years. The aim of this study was to investigate the outcome of pregnancy in women with diagnosis of cancer; in particular, neonatal morbidity and mortality, after in utero exposure to chemotherapy, were evaluated. A total of 59 singletons and one twin pregnancy complicated by cancer were followed at our tertiary centre over the last 15 years. A different treatment, based on surgery and/or chemotherapy in pregnancy or delayed to the postpartum period, was employed. There were 59 live births (97%), one foetal loss and one stillbirth at 28 weeks. The congenital malformation rate was 5% (n = 3). The rate of preterm birth was 83%. The mean birthweight and mean birthweight percentile were 2,098 g (740-3930) and 46 (7-93), respectively; 32% of neonates were small for gestational age (SGA). Dividing the population into treated or untreated with chemotherapy, the rate of SGA was not statistically significant different between the two groups. Our results showed that chemotherapy administered during the second trimester or later did not influence intrauterine foetal growth, but the high prevalence of SGA neonates in the two groups, exposed or not exposed to chemotherapy, suggests an influence of maternal cancer per se on foetal growth.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Complicaciones Neoplásicas del Embarazo
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Efectos Tardíos de la Exposición Prenatal
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Anomalías Congénitas
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Protocolos de Quimioterapia Combinada Antineoplásica
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Nacimiento Prematuro
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Neoplasias
Tipo de estudio:
Observational_studies
Límite:
Adult
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Female
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Humans
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Infant
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Newborn
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Pregnancy
Idioma:
En
Revista:
Eur J Cancer Care (Engl)
Asunto de la revista:
ENFERMAGEM
/
NEOPLASIAS
Año:
2017
Tipo del documento:
Article
País de afiliación:
Italia