Low serum prealbumin levels in post-stroke depression.
Psychiatry Res
; 246: 149-153, 2016 Dec 30.
Article
en En
| MEDLINE
| ID: mdl-27693925
ABSTRACT
Previous studies have shown that prealbumin is associated with depression. However, the association between prealbumin and post-stroke depression remains unelucidated. This observational cohort study determined whether low baseline serum prealbumin could predict post-stroke depression at 1 month in patients admitted with acute stroke. The study, conducted from October 2013 to September 2014, included 307 patients with acute stroke who were followed-up for 1 month. Serum prealbumin was measured within 24h after admission using an immunoturbidimetric method. The17-item Hamilton Depression Scale was used to evaluate depression symptoms. Patients with a depression score of ≥7 were evaluated using the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, 4th edition, for diagnosing post-stroke depression at 1 month. Binary logistic regression analysis was used to evaluate possible predictors of post-stroke depression. Overall, 93 (30.3%) patients were diagnosed with post-stroke depression. Serum prealbumin was significantly lower in patients with versus those without post-stroke depression, and was a significant predictor of post-stroke depression after adjusting for confounding risk factors. In conclusion, baseline serum prealbumin level was associated with post-stroke depression at 1 month, suggesting that prealbumin might be a useful biomarker for post-stroke depression.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Prealbúmina
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Accidente Cerebrovascular
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Depresión
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Trastorno Depresivo
Tipo de estudio:
Etiology_studies
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Guideline
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Qualitative_research
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Risk_factors_studies
Límite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Psychiatry Res
Año:
2016
Tipo del documento:
Article
País de afiliación:
China