Synthesis of Coumestrol and Aureol.
J Nat Prod
; 79(10): 2749-2753, 2016 10 28.
Article
en En
| MEDLINE
| ID: mdl-27704859
ABSTRACT
A total synthesis of coumestrol (1) and aureol (2) is described. The Perkin condensation of 2-bromo-4-hydroxylphenylacetic acid (6) and o-hydroxybenzaldehydes (7) gave the corresponding 2'-bromo-3-arylcoumarins (9). A copper-catalyzed consecutive hydroxylation and aerobic oxidative coupling of 9 under microwave conditions facilitated the total synthesis of 1 and 2, respectively, with spectroscopic data highly similar to those of natural products.
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Bases de datos:
MEDLINE
Asunto principal:
Sesquiterpenos
/
Cumestrol
Idioma:
En
Revista:
J Nat Prod
Año:
2016
Tipo del documento:
Article