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Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer.
Lesseur, Corina; Diergaarde, Brenda; Olshan, Andrew F; Wünsch-Filho, Victor; Ness, Andrew R; Liu, Geoffrey; Lacko, Martin; Eluf-Neto, José; Franceschi, Silvia; Lagiou, Pagona; Macfarlane, Gary J; Richiardi, Lorenzo; Boccia, Stefania; Polesel, Jerry; Kjaerheim, Kristina; Zaridze, David; Johansson, Mattias; Menezes, Ana M; Curado, Maria Paula; Robinson, Max; Ahrens, Wolfgang; Canova, Cristina; Znaor, Ariana; Castellsagué, Xavier; Conway, David I; Holcátová, Ivana; Mates, Dana; Vilensky, Marta; Healy, Claire M; Szeszenia-Dabrowska, Neonila; Fabiánová, Eleonóra; Lissowska, Jolanta; Grandis, Jennifer R; Weissler, Mark C; Tajara, Eloiza H; Nunes, Fabio D; de Carvalho, Marcos B; Thomas, Steve; Hung, Rayjean J; Peters, Wilbert H M; Herrero, Rolando; Cadoni, Gabriella; Bueno-de-Mesquita, H Bas; Steffen, Annika; Agudo, Antonio; Shangina, Oxana; Xiao, Xiangjun; Gaborieau, Valérie; Chabrier, Amélie; Anantharaman, Devasena.
Afiliación
  • Lesseur C; International Agency for Research on Cancer (IARC/WHO), Lyon, France.
  • Diergaarde B; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Olshan AF; University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA.
  • Wünsch-Filho V; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
  • Ness AR; UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina, USA.
  • Liu G; Faculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil.
  • Lacko M; National Institute for Health Research (NIHR) Biomedical Research Unit in Nutrition, Diet and Lifestyle at the University Hospitals Bristol NHS Foundation Trust and the University of Bristol, Bristol, UK.
  • Eluf-Neto J; School of Oral and Dental Sciences, University of Bristol, Bristol, UK.
  • Franceschi S; Princess Margaret Cancer Centre, Toronto, Ontario, Canada.
  • Lagiou P; Department of Otorhinolaryngology, Head and Neck Surgery, Maastricht University Medical Center, Maastricht, the Netherlands.
  • Macfarlane GJ; Departamento de Medicina Preventiva, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
  • Richiardi L; International Agency for Research on Cancer (IARC/WHO), Lyon, France.
  • Boccia S; Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
  • Polesel J; School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, UK.
  • Kjaerheim K; Department of Medical Sciences, University of Turin, Turin, Italy.
  • Zaridze D; Section of Hygiene, Institute of Public Health, Università Cattolica del Sacro Cuore, Fondazione Policlinico 'Agostino Gemelli', Rome, Italy.
  • Johansson M; Unit of Cancer Epidemiology, CRO Aviano National Cancer Institute, Aviano, Italy.
  • Menezes AM; Cancer Registry of Norway, Oslo, Norway.
  • Curado MP; Department of Cancer Epidemiology and Prevention, Institute of Carcinogenesis, N.N. Blokhin Russian Cancer Research Centre of the Russian Ministry of Health, Moscow, Russian Federation.
  • Robinson M; International Agency for Research on Cancer (IARC/WHO), Lyon, France.
  • Ahrens W; Programa de Pós-Graduacão em Epidemiologia, Universidade Federal de Pelotas (UFPel), Pelotas, Brazil.
  • Canova C; Epidemiology, International Center for Research (CIPE), A.C. Camargo Cancer Center, Sao Paulo, Brazil.
  • Znaor A; Centre for Oral Health Research, Newcastle University, Newcastle, UK.
  • Castellsagué X; Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany.
  • Conway DI; Deparment of Molecular Medicine, University of Padova, Padova, Italy.
  • Holcátová I; International Agency for Research on Cancer (IARC/WHO), Lyon, France.
  • Mates D; Croatian National Institute of Public Health, Zagreb, Croatia.
  • Vilensky M; Institut Català d'Oncologia (ICO)-IDIBELL, CIBERESP, l'Hospitalet de Llobregat, Barcelona, Spain.
  • Healy CM; School of Medicine, Dentistry and Nursing, University of Glasgow, Glasgow, UK.
  • Szeszenia-Dabrowska N; NHS National Services Scotland (NSS), Edinburgh, UK.
  • Fabiánová E; Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.
  • Lissowska J; National Institute of Public Health, Bucharest, Romania.
  • Grandis JR; Instituto de Oncología 'Angel H. Roffo', Universidad de Buenos Aires, Buenos Aires, Argentina.
  • Weissler MC; Trinity College School of Dental Science, Dublin, Ireland.
  • Tajara EH; Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Lodz, Poland.
  • Nunes FD; Regional Authority of Public Health, Banská Bystrica, Slovakia.
  • de Carvalho MB; Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology (MCMCC), Warsaw, Poland.
  • Thomas S; Department of Otolaryngology-Head and Neck Surgery, University of California at San Francisco, San Francisco, California, USA.
  • Hung RJ; Clinical Translational Science Institute, University of California at San Francisco, San Francisco, California, USA.
  • Peters WH; Department of Otolaryngology/Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
  • Herrero R; Department of Molecular Biology, School of Medicine of São José do Rio Preto, São José do Rio Preto, Brazil.
  • Cadoni G; Department of Stomatology, School of Dentistry, University of São Paulo, São Paulo, Brazil.
  • Bueno-de-Mesquita HB; Department of Head and Neck Surgery, Heliópolis Hospital, São Paulo, Brazil.
  • Steffen A; School of Oral and Dental Sciences, University of Bristol, Bristol, UK.
  • Agudo A; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
  • Shangina O; Department of Gastroenterology, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands.
  • Xiao X; International Agency for Research on Cancer (IARC/WHO), Lyon, France.
  • Gaborieau V; Institute of Otorhinolaryngology, Università Cattolica del Sacro Cuore, Fondazione Policlinico 'Agostino Gemelli', Rome, Italy.
  • Chabrier A; Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.
  • Anantharaman D; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Nat Genet ; 48(12): 1544-1550, 2016 12.
Article en En | MEDLINE | ID: mdl-27749845
We conducted a genome-wide association study of oral cavity and pharyngeal cancer in 6,034 cases and 6,585 controls from Europe, North America and South America. We detected eight significantly associated loci (P < 5 × 10-8), seven of which are new for these cancer sites. Oral and pharyngeal cancers combined were associated with loci at 6p21.32 (rs3828805, HLA-DQB1), 10q26.13 (rs201982221, LHPP) and 11p15.4 (rs1453414, OR52N2-TRIM5). Oral cancer was associated with two new regions, 2p23.3 (rs6547741, GPN1) and 9q34.12 (rs928674, LAMC3), and with known cancer-related loci-9p21.3 (rs8181047, CDKN2B-AS1) and 5p15.33 (rs10462706, CLPTM1L). Oropharyngeal cancer associations were limited to the human leukocyte antigen (HLA) region, and classical HLA allele imputation showed a protective association with the class II haplotype HLA-DRB1*1301-HLA-DQA1*0103-HLA-DQB1*0603 (odds ratio (OR) = 0.59, P = 2.7 × 10-9). Stratified analyses on a subgroup of oropharyngeal cases with information available on human papillomavirus (HPV) status indicated that this association was considerably stronger in HPV-positive (OR = 0.23, P = 1.6 × 10-6) than in HPV-negative (OR = 0.75, P = 0.16) cancers.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Variación Genética / Neoplasias de la Boca / Neoplasias Faríngeas / Marcadores Genéticos / Predisposición Genética a la Enfermedad / Infecciones por Papillomavirus / Estudio de Asociación del Genoma Completo Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Genet Asunto de la revista: GENETICA MEDICA Año: 2016 Tipo del documento: Article País de afiliación: Francia
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Variación Genética / Neoplasias de la Boca / Neoplasias Faríngeas / Marcadores Genéticos / Predisposición Genética a la Enfermedad / Infecciones por Papillomavirus / Estudio de Asociación del Genoma Completo Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Genet Asunto de la revista: GENETICA MEDICA Año: 2016 Tipo del documento: Article País de afiliación: Francia