Directional Potassium Transport through a Unimolecular Peptide Channel.
Angew Chem Int Ed Engl
; 55(47): 14678-14682, 2016 11 14.
Article
en En
| MEDLINE
| ID: mdl-27754610
ABSTRACT
Three unimolecular peptide channels have been designed and prepared by using the ß-helical conformation of gramicidinâ
A (gA). The new peptides bear one to three NH3+ groups at the N-end and one to three CO2- groups at the C-end. These zwitterionic peptides were inserted into lipid bilayers in an orientation-selective manner. Conductance experiments on planar lipid bilayers showed that this orientation bias could lead to observable directional K+ transport under multi-channel conditions. This directional transport behavior can further cause the generation of a current across a planar bilayer without applying a voltage. More importantly, in vesicles with identical external and internal KCl concentrations, the channels can pump K+ across the lipid bilayer and cause a membrane potential.
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1
Bases de datos:
MEDLINE
Asunto principal:
Potasio
/
Gramicidina
Idioma:
En
Revista:
Angew Chem Int Ed Engl
Año:
2016
Tipo del documento:
Article
País de afiliación:
China