BDNF mRNA abundance regulated by antidromic action potentials and AP-LTD in hippocampus.
Neurosci Lett
; 635: 97-102, 2016 Dec 02.
Article
en En
| MEDLINE
| ID: mdl-27760383
ABSTRACT
Action-potential-induced LTD (AP-LTD) is a form of synaptic plasticity that reduces synaptic strength in CA1 hippocampal neurons firing antidromically during sharp-wave ripples. This firing occurs during slow-wave sleep and quiet moments of wakefulness, which are periods of offline replay of neural sequences learned during encoding sensory information. Here we report that rapid and persistent down-regulation of different mRNA transcripts of the BDNF gene accompanies AP-LTD, and that AP-LTD is abolished in mice with the BDNF gene knocked out in CA1 hippocampal neurons. These findings increase understanding of the mechanism of AP-LTD and the cellular mechanisms of memory consolidation.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Potenciales de Acción
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ARN Mensajero
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Factor Neurotrófico Derivado del Encéfalo
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Depresión Sináptica a Largo Plazo
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Hipocampo
Límite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Año:
2016
Tipo del documento:
Article
País de afiliación:
Estados Unidos