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Metabolism-based structure optimization: Discovery of a potent and orally available tyrosine kinase ALK inhibitor bearing the tetracyclic benzo[b]carbazolone core.
Han, Mei; Wang, Chengyan; Ji, Yinchun; Song, Zilan; Xing, Li; Su, Yi; Wang, Xisheng; Zhang, Ao; Ai, Jing; Geng, Meiyu.
Afiliación
  • Han M; Department of Pharmacology and Glycobiology, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
  • Wang C; Nano Science and Technology Institute, University of Science and Technology of China, Suzhou 215123, China.
  • Ji Y; Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai 201203, China.
  • Song Z; CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai 201203, China.
  • Xing L; CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai 201203, China.
  • Su Y; Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai 201203, China.
  • Wang X; Nano Science and Technology Institute, University of Science and Technology of China, Suzhou 215123, China.
  • Zhang A; CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: aozhang@simm.ac.cn.
  • Ai J; Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: jai@simm.ac.cn.
  • Geng M; Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: mygeng@simm.ac.cn.
Bioorg Med Chem Lett ; 26(22): 5399-5402, 2016 11 15.
Article en En | MEDLINE | ID: mdl-27769623
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Derivados del Benceno / Proteínas Tirosina Quinasas Receptoras / Inhibidores de Proteínas Quinasas / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2016 Tipo del documento: Article País de afiliación: China
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Derivados del Benceno / Proteínas Tirosina Quinasas Receptoras / Inhibidores de Proteínas Quinasas / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2016 Tipo del documento: Article País de afiliación: China