Gemcitabine treatment enhanced the anti-tumor effect of cytokine induced killer cells by depletion of CD4<sup>+</sup>CD25<sup>bri</sup> regulatory T cells.

Zhao, Peng; Zhu, Danni; Zhang, Zhen; Han, Bin; Gao, Daiqing; Wei, Xiaofang; Xie, Xihe; Li, Changyou; Sun, Weihong; Wang, Qingqing; Guo, Qingming

Gemcitabine treatment enhanced the anti-tumor effect of cytokine induced killer cells by depletion of CD4⁺CD25^bri regulatory T cells.

Zhao, Peng; Zhu, Danni; Zhang, Zhen; Han, Bin; Gao, Daiqing; Wei, Xiaofang; Xie, Xihe; Li, Changyou; Sun, Weihong; Wang, Qingqing; Guo, Qingming.

Afiliación

Zhao P; Biotherapy Center, Qingdao Central Hospital, The Second Affiliated Hospital of Qingdao University Medical College, Qingdao 266042, PR China.
Zhu D; Biotherapy Center, Qingdao Central Hospital, The Second Affiliated Hospital of Qingdao University Medical College, Qingdao 266042, PR China.
Zhang Z; Biotherapy Center, Qingdao Central Hospital, The Second Affiliated Hospital of Qingdao University Medical College, Qingdao 266042, PR China.
Han B; Institute of Transfusion Medicine, Qingdao Blood Center, Qingdao 266071, PR China.
Gao D; Biotherapy Center, Qingdao Central Hospital, The Second Affiliated Hospital of Qingdao University Medical College, Qingdao 266042, PR China.
Wei X; Biotherapy Center, Qingdao Central Hospital, The Second Affiliated Hospital of Qingdao University Medical College, Qingdao 266042, PR China.
Xie X; Biotherapy Center, Qingdao Central Hospital, The Second Affiliated Hospital of Qingdao University Medical College, Qingdao 266042, PR China.
Li C; Biotherapy Center, Qingdao Central Hospital, The Second Affiliated Hospital of Qingdao University Medical College, Qingdao 266042, PR China.
Sun W; Biotherapy Center, Qingdao Central Hospital, The Second Affiliated Hospital of Qingdao University Medical College, Qingdao 266042, PR China.
Wang Q; Institute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, PR China.
Guo Q; Biotherapy Center, Qingdao Central Hospital, The Second Affiliated Hospital of Qingdao University Medical College, Qingdao 266042, PR China. Electronic address: qingming_677@163.com.

Immunol Lett ; 181: 36-44, 2017 01.

Article en En | MEDLINE | ID: mdl-27867030

Asunto(s)

Células Asesinas Inducidas por Citocinas/efectos de los fármacos; Células Asesinas Inducidas por Citocinas/inmunología; Desoxicitidina/análogos & derivados; Inmunomodulación/efectos de los fármacos; Neoplasias/inmunología; Subgrupos de Linfocitos T/inmunología; Linfocitos T Reguladores/inmunología; Animales; Antimetabolitos Antineoplásicos/farmacología; Apoptosis; Biomarcadores; Línea Celular Tumoral; Proliferación Celular/efectos de los fármacos; Supervivencia Celular/efectos de los fármacos; Células Asesinas Inducidas por Citocinas/metabolismo; Citocinas/metabolismo; Citotoxicidad Inmunológica; Desoxicitidina/farmacología; Modelos Animales de Enfermedad; Progresión de la Enfermedad; Relación Dosis-Respuesta a Droga; Humanos; Inmunosupresores/farmacología; Depleción Linfocítica; Masculino; Ratones; Neoplasias/tratamiento farmacológico; Neoplasias/metabolismo; Neoplasias/patología; Fenotipo; Subgrupos de Linfocitos T/metabolismo; Linfocitos T Reguladores/metabolismo; Gemcitabina

Palabras clave

Gemcitabine cytokine induced killer cells CD4(+)CD25(bri) regulatory T cells cytotoxicity

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Subgrupos de Linfocitos T / Linfocitos T Reguladores / Desoxicitidina / Células Asesinas Inducidas por Citocinas / Inmunomodulación / Neoplasias Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Immunol Lett Año: 2017 Tipo del documento: Article

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