Subcutaneous rotenone rat model of Parkinson's disease: Dose exploration study.

Zhang, Zhen-Nian; Zhang, Jing-Si; Xiang, Jun; Yu, Zhong-Hai; Zhang, Wen; Cai, Min; Li, Xiang-Ting; Wu, Ting; Li, Wen-Wei; Cai, Ding-Fang

Zhang, Zhen-Nian; Zhang, Jing-Si; Xiang, Jun; Yu, Zhong-Hai; Zhang, Wen; Cai, Min; Li, Xiang-Ting; Wu, Ting; Li, Wen-Wei; Cai, Ding-Fang.

Afiliación

Zhang ZN; Department of Integrative Medicine, Zhongshan Hospital, Laboratory of Neurology, Institute of Integrative Medicine, Fudan University, 180 Fenglin Road, Shanghai 200032, China.
Zhang JS; Department of Integrative Medicine, Zhongshan Hospital, Laboratory of Neurology, Institute of Integrative Medicine, Fudan University, 180 Fenglin Road, Shanghai 200032, China.
Xiang J; Department of Integrative Medicine, Zhongshan Hospital, Laboratory of Neurology, Institute of Integrative Medicine, Fudan University, 180 Fenglin Road, Shanghai 200032, China.
Yu ZH; Department of Integrative Medicine, Zhongshan Hospital, Laboratory of Neurology, Institute of Integrative Medicine, Fudan University, 180 Fenglin Road, Shanghai 200032, China.
Zhang W; Department of Integrative Medicine, Zhongshan Hospital, Laboratory of Neurology, Institute of Integrative Medicine, Fudan University, 180 Fenglin Road, Shanghai 200032, China.
Cai M; Department of Integrative Medicine, Zhongshan Hospital, Laboratory of Neurology, Institute of Integrative Medicine, Fudan University, 180 Fenglin Road, Shanghai 200032, China.
Li XT; Department of Integrative Medicine, Zhongshan Hospital, Laboratory of Neurology, Institute of Integrative Medicine, Fudan University, 180 Fenglin Road, Shanghai 200032, China.
Wu T; Department of Integrative Medicine, Zhongshan Hospital, Laboratory of Neurology, Institute of Integrative Medicine, Fudan University, 180 Fenglin Road, Shanghai 200032, China.
Li WW; Department of Integrative Medicine, Zhongshan Hospital, Laboratory of Neurology, Institute of Integrative Medicine, Fudan University, 180 Fenglin Road, Shanghai 200032, China.
Cai DF; Department of Integrative Medicine, Zhongshan Hospital, Laboratory of Neurology, Institute of Integrative Medicine, Fudan University, 180 Fenglin Road, Shanghai 200032, China. Electronic address: dingfangcai@163.com.

Brain Res ; 1655: 104-113, 2017 01 15.

Article en En | MEDLINE | ID: mdl-27876560

Asunto(s)

Trastornos Parkinsonianos; Rotenona/administración & dosificación; Animales; Peso Corporal/efectos de los fármacos; Cuerpo Estriado/efectos de los fármacos; Cuerpo Estriado/metabolismo; Cuerpo Estriado/patología; Dopamina/metabolismo; Relación Dosis-Respuesta a Droga; Inyecciones Subcutáneas; Masculino; Mitocondrias/efectos de los fármacos; Mitocondrias/metabolismo; Mitocondrias/patología; Actividad Motora/efectos de los fármacos; Neuronas/efectos de los fármacos; Neuronas/metabolismo; Neuronas/patología; Trastornos Parkinsonianos/inducido químicamente; Trastornos Parkinsonianos/mortalidad; Trastornos Parkinsonianos/patología; Trastornos Parkinsonianos/fisiopatología; Distribución Aleatoria; Ratas Wistar; Prueba de Desempeño de Rotación con Aceleración Constante; Sustancia Negra/efectos de los fármacos; Sustancia Negra/metabolismo; Sustancia Negra/patología; Tirosina 3-Monooxigenasa/metabolismo; alfa-Sinucleína/metabolismo

Palabras clave

Animal model; Parkinson's disease; Rotenone; α-synuclein

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Rotenona / Trastornos Parkinsonianos Límite: Animals Idioma: En Revista: Brain Res Año: 2017 Tipo del documento: Article País de afiliación: China

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