Lignans from Opuntia ficus-indica seeds protect rat primary hepatocytes and HepG2 cells against ethanol-induced oxidative stress.
Biosci Biotechnol Biochem
; 81(1): 181-183, 2017 Jan.
Article
en En
| MEDLINE
| ID: mdl-27885940
Bioactivity-guided isolation of Opuntia ficus-indica (Cactaceae) seeds against ethanol-treated primary rat hepatocytes yielded six lignan compounds. Among the isolates, furofuran lignans 4-6, significantly protected rat hepatocytes against ethanol-induced oxidative stress by reducing intracellular reactive oxygen species levels, preserving antioxidative defense enzyme activities, and maintaining the glutathione content. Moreover, 4 dose-dependently induced the heme oxygenase-1 expression in HepG2 cells.
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Bases de datos:
MEDLINE
Asunto principal:
Semillas
/
Lignanos
/
Estrés Oxidativo
/
Citoprotección
/
Hepatocitos
/
Opuntia
/
Etanol
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Biosci Biotechnol Biochem
Asunto de la revista:
BIOQUIMICA
/
BIOTECNOLOGIA
Año:
2017
Tipo del documento:
Article