Anthropometrics and prognosis in diffuse large B-cell lymphoma: a multicentre study of 653 patients.
Eur J Haematol
; 98(4): 355-362, 2017 Apr.
Article
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| MEDLINE
| ID: mdl-27893172
ABSTRACT
OBJECTIVE:
The impact of body mass index (BMI) and body surface area (BSA) on survival in diffuse large B-cell lymphoma (DLBCL) is controversial. Recent studies show superior outcomes for overweight and obese patients. PATIENTS ANDMETHODS:
A total of 653 R-CHOP(-like)-treated DLBCL patients were included in this retrospective cohort study. Patients, baseline clinicopathologic characteristics and treatment information were retrieved from the Danish Lymphoma Registry. Anthropometric measures were obtained from chemotherapy prescription charts.RESULTS:
Underweight (BMI <18.5 kg/m2 ) was associated with significantly worse progression-free survival (PFS) for male patients only in sex-stratified analyses (HR 3.92, 95% CI 1.57-9.75, P = 0.003, for males; HR 1.65, 95% CI 0.90-3.02, P = 0.107, for females). In multivariate analyses, underweight was associated with worse PFS for both sexes (HR 5.34, 95% CI 2.07-13.79, P = 0.001, for males; HR 2.14, 95% CI 1.12-4.08, P = 0.021, for females). Similar results were obtained in analyses of overall survival. In crude analyses, BSA <1.8 m2 was associated with worse PFS for men and women (HR 1.65, 95% CI 1.03-2.65, P = 0.039, for men; HR 1.62, 95% CI 1.03-2.56, P = 0.037, for women). In multivariate analyses, however, these associations diminished.CONCLUSIONS:
Our study demonstrates that underweight DLBCL patients have worse outcomes following R-CHOP as compared to normal as well as overweight patients.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Superficie Corporal
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Protocolos de Quimioterapia Combinada Antineoplásica
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Índice de Masa Corporal
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Linfoma de Células B Grandes Difuso
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Sobrepeso
Tipo de estudio:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Aged
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Female
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Humans
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Male
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Middle aged
País/Región como asunto:
Europa
Idioma:
En
Revista:
Eur J Haematol
Asunto de la revista:
HEMATOLOGIA
Año:
2017
Tipo del documento:
Article
País de afiliación:
Dinamarca