The Presence of HPV DNA in Neck Lymph Node Metastasis Correlates with Improved Overall Survival of Patients with Oropharyngeal Cancer Undergoing Surgical Treatment.
Oncology
; 92(2): 87-93, 2017.
Article
en En
| MEDLINE
| ID: mdl-27902986
ABSTRACT
BACKGROUND:
Few studies have addressed how human papilloma virus (HPV) infection in oropharyngeal squamous cell carcinoma (OPSCC) affects the outcome of surgical therapy; furthermore, the relationship between the presence of HPV DNA and neck lymph node (LN) metastasis has not been well established.METHODS:
A total of 65 patients who underwent surgery as a first-line therapy for OPSCC were enrolled in this study. In HPV-positive patients, the presence of HPV DNA in metastatic neck LN lesions was evaluated.RESULTS:
The HPV-positive patients had significantly better overall survival than the HPV-negative patients (log-rank test, p = 0.04), whereas HPV infection status did not significantly affect disease-free survival (log-rank test, p = 0.65). In all of the HPV-positive OPSCC patients who developed cervical LN metastasis, the same HPV DNA type was found in both the primary tumour and the metastases.CONCLUSIONS:
The present results suggest that HPV infection is a determining factor for good prognosis in patients undergoing first-line surgical therapy for OPSCC.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
ADN Viral
/
Carcinoma de Células Escamosas
/
Neoplasias Orofaríngeas
/
Alphapapillomavirus
/
Metástasis Linfática
Tipo de estudio:
Prognostic_studies
Límite:
Aged
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Oncology
Año:
2017
Tipo del documento:
Article
País de afiliación:
Japón