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The IDH2 R172K mutation associated with angioimmunoblastic T-cell lymphoma produces 2HG in T cells and impacts lymphoid development.
Lemonnier, François; Cairns, Rob A; Inoue, Satoshi; Li, Wanda Y; Dupuy, Aurélie; Broutin, Sophie; Martin, Nadine; Fataccioli, Virginie; Pelletier, Romain; Wakeham, Andrew; Snow, Bryan E; de Leval, Laurence; Pujals, Anais; Haioun, Corinne; Paci, Angelo; Tobin, Erica R; Narayanaswamy, Rohini; Yen, Katherine; Jin, Shengfang; Gaulard, Philippe; Mak, Tak W.
Afiliación
  • Lemonnier F; The Campbell Family Institute for Breast Cancer Research at Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.
  • Cairns RA; Inserm U955, Université Paris Est Créteil, Institut Mondor de Recherche Biomédicale, 94010 Créteil, France.
  • Inoue S; The Campbell Family Institute for Breast Cancer Research at Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.
  • Li WY; The Campbell Family Institute for Breast Cancer Research at Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.
  • Dupuy A; The Campbell Family Institute for Breast Cancer Research at Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.
  • Broutin S; Inserm U955, Université Paris Est Créteil, Institut Mondor de Recherche Biomédicale, 94010 Créteil, France.
  • Martin N; Service de Pharmacologie, Département de Biologie et Pathologie Médicales, Gustave Roussy, Université Paris-Saclay, F-94805, Villejuif, France.
  • Fataccioli V; Inserm U955, Université Paris Est Créteil, Institut Mondor de Recherche Biomédicale, 94010 Créteil, France.
  • Pelletier R; Inserm U955, Université Paris Est Créteil, Institut Mondor de Recherche Biomédicale, 94010 Créteil, France.
  • Wakeham A; Inserm U955, Université Paris Est Créteil, Institut Mondor de Recherche Biomédicale, 94010 Créteil, France.
  • Snow BE; The Campbell Family Institute for Breast Cancer Research at Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.
  • de Leval L; The Campbell Family Institute for Breast Cancer Research at Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.
  • Pujals A; Institut Universitaire de Pathologie, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland.
  • Haioun C; Inserm U955, Université Paris Est Créteil, Institut Mondor de Recherche Biomédicale, 94010 Créteil, France.
  • Paci A; Unité Hémopathies Lymphoïdes, Groupe Henri-Mondor Albert-Chenevier, Assistance Publique-Hôpitaux de Paris, 94010, Créteil, France.
  • Tobin ER; Service de Pharmacologie, Département de Biologie et Pathologie Médicales, Gustave Roussy, Université Paris-Saclay, F-94805, Villejuif, France.
  • Narayanaswamy R; Agios Pharmaceuticals, Cambridge, MA 02139.
  • Yen K; Agios Pharmaceuticals, Cambridge, MA 02139.
  • Jin S; Agios Pharmaceuticals, Cambridge, MA 02139.
  • Gaulard P; Agios Pharmaceuticals, Cambridge, MA 02139; tmak@uhnresearch.ca philippe.gaulard@aphp.fr shengfang.jin@agios.com.
  • Mak TW; Inserm U955, Université Paris Est Créteil, Institut Mondor de Recherche Biomédicale, 94010 Créteil, France; tmak@uhnresearch.ca philippe.gaulard@aphp.fr shengfang.jin@agios.com.
Proc Natl Acad Sci U S A ; 113(52): 15084-15089, 2016 12 27.
Article en En | MEDLINE | ID: mdl-27956631
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Linfoma de Células T / Glutaratos / Isocitrato Deshidrogenasa Tipo de estudio: Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2016 Tipo del documento: Article País de afiliación: Canadá
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Linfoma de Células T / Glutaratos / Isocitrato Deshidrogenasa Tipo de estudio: Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2016 Tipo del documento: Article País de afiliación: Canadá