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Identification of a diverse synthetic abietane diterpenoid library for anticancer activity.
Xu, Hongtao; Liu, Lili; Fan, Xiaoting; Zhang, Guanjun; Li, Yuanchao; Jiang, Biao.
Afiliación
  • Xu H; Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai 201210, PR China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China.
  • Liu L; Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai 201210, PR China.
  • Fan X; Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai 201210, PR China; Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, PR China.
  • Zhang G; College of Chemical Engineering and Materials Science, Tianjin University of Science & Technology, Tianjin 300457, PR China.
  • Li Y; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China.
  • Jiang B; Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai 201210, PR China. Electronic address: jiangbiao@shanghaitech.edu.cn.
Bioorg Med Chem Lett ; 27(3): 505-510, 2017 02 01.
Article en En | MEDLINE | ID: mdl-28011223
A diverse natural-product-like synthetic abietane diterpenoid library contains about 56 compounds were obtained, and evaluated for their potential in vitro cytotoxic or antitumor activity against A549, PC-3 and SKOV-3 tumor cell lines by SRB assay. Treatment of A549 cells with the most potent compound ketone 19 showed induction of apoptosis, as revealed by JC-1 mitochondrial membrane potential staining, TUNNEL assay, western blotting analysis and flow cytometry assay.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Abietanos / Antineoplásicos Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2017 Tipo del documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Abietanos / Antineoplásicos Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2017 Tipo del documento: Article