Loss of Cyclin-dependent Kinase 2 in the Pancreas Links Primary ß-Cell Dysfunction to Progressive Depletion of ß-Cell Mass and Diabetes.

Kim, So Yoon; Lee, Ji-Hyeon; Merrins, Matthew J; Gavrilova, Oksana; Bisteau, Xavier; Kaldis, Philipp; Satin, Leslie S; Rane, Sushil G

Kim, So Yoon; Lee, Ji-Hyeon; Merrins, Matthew J; Gavrilova, Oksana; Bisteau, Xavier; Kaldis, Philipp; Satin, Leslie S; Rane, Sushil G.

Afiliación

Kim SY; From the Cell Growth and Metabolism Section, Diabetes, Endocrinology, and Obesity Branch and.
Lee JH; From the Cell Growth and Metabolism Section, Diabetes, Endocrinology, and Obesity Branch and.
Merrins MJ; the Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin, Madison, Wisconsin 53705.
Gavrilova O; the Mouse Metabolism Core Laboratory, NIDDK, National Institutes of Health, Clinical Research Center, Bethesda, Maryland 20892.
Bisteau X; the Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research), 61 Biopolis Drive, Proteos#3-09, Singapore 138673, Singapore.
Kaldis P; the Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research), 61 Biopolis Drive, Proteos#3-09, Singapore 138673, Singapore.
Satin LS; the Department of Biochemistry, National University of Singapore, Singapore 117597, Singapore, and.
Rane SG; the Department of Pharmacology and Brehm Center for Diabetes Research, University of Michigan Medical School, Ann Arbor, Michigan 48105.

J Biol Chem ; 292(9): 3841-3853, 2017 03 03.

Article en En | MEDLINE | ID: mdl-28100774

Asunto(s)

Quinasa 2 Dependiente de la Ciclina/metabolismo; Diabetes Mellitus Experimental/patología; Células Secretoras de Insulina/patología; Páncreas/patología; Animales; Peso Corporal; Proliferación Celular; Quinasa 2 Dependiente de la Ciclina/genética; Dieta Alta en Grasa; Progresión de la Enfermedad; Femenino; Genotipo; Glucosa/química; Prueba de Tolerancia a la Glucosa; Humanos; Insulina/metabolismo; Secreción de Insulina; Células Secretoras de Insulina/citología; Masculino; Ratones; Ratones Noqueados; Microscopía Fluorescente; Fenotipo; Fosforilación

Palabras clave

CDK2; FOXO; beta cell (B-cell); beta cell function; beta cell mass; cell cycle; cyclin-dependent kinase (CDK); diabetes; foxo1

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Páncreas / Diabetes Mellitus Experimental / Células Secretoras de Insulina / Quinasa 2 Dependiente de la Ciclina Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: J Biol Chem Año: 2017 Tipo del documento: Article

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google