Medicinal attributes of 1,2,3-triazoles: Current developments.
Bioorg Chem
; 71: 30-54, 2017 04.
Article
en En
| MEDLINE
| ID: mdl-28126288
ABSTRACT
1,2,3-Triazoles are important five-membered heterocyclic scaffold due to their extensive biological activities. This framework can be readily obtained in good to excellent yields on the multigram scale through click chemistry via reaction of aryl/alkyl halides, alkynes and NaN3 under ambient conditions. It has been an emerging area of interest for many researchers throughout the globe owing to its immense pharmacological scope. The present work aims to summarize the current approaches adopted for the synthesis of the 1,2,3-triazole and medicinal significance of these architectures as a lead structure for the discovery of drug molecules such as COX-1/COX-2 inhibitors (celecoxib, pyrazofurin), HIV protease inhibitors, CB1 cannabinoid receptor antagonist and much more which are in the pipeline of clinical trials. The emphasis has been given on the major advancements in the medicinal prospectus of this pharmacophore for the period during 2008-2016.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Triazoles
/
Descubrimiento de Drogas
/
Química Clic
Límite:
Animals
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Humans
Idioma:
En
Revista:
Bioorg Chem
Año:
2017
Tipo del documento:
Article
País de afiliación:
India