BACE1 Dynamics Upon Inhibition with a BACE Inhibitor and Correlation to Downstream Alzheimer's Disease Markers in Elderly Healthy Participants.

Timmers, Maarten; Barão, Soraia; Van Broeck, Bianca; Tesseur, Ina; Slemmon, John; De Waepenaert, Katja; Bogert, Jennifer; Shaw, Leslie M; Engelborghs, Sebastiaan; Moechars, Dieder; Mercken, Marc; Van Nueten, Luc; Tritsmans, Luc; de Strooper, Bart; Streffer, Johannes Rolf

Timmers, Maarten; Barão, Soraia; Van Broeck, Bianca; Tesseur, Ina; Slemmon, John; De Waepenaert, Katja; Bogert, Jennifer; Shaw, Leslie M; Engelborghs, Sebastiaan; Moechars, Dieder; Mercken, Marc; Van Nueten, Luc; Tritsmans, Luc; de Strooper, Bart; Streffer, Johannes Rolf.

Afiliación

Timmers M; Janssen Research and Development, A Division of Janssen Pharmaceutica N.V., Beerse, Belgium.
Barão S; Reference Center for Biological Markers of Dementia (BIODEM), Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
Van Broeck B; VIB Center for the Biology of Disease, VIB-Leuven, Belgium.
Tesseur I; Center for Human Genetics, Universitaire ziekenhuizen and LIND, KU Leuven, Belgium.
Slemmon J; Janssen Research and Development, A Division of Janssen Pharmaceutica N.V., Beerse, Belgium.
De Waepenaert K; Janssen Research and Development, A Division of Janssen Pharmaceutica N.V., Beerse, Belgium.
Bogert J; Janssen Research and Development LLC, La Jolla, CA, USA.
Shaw LM; Janssen Research and Development, A Division of Janssen Pharmaceutica N.V., Beerse, Belgium.
Engelborghs S; Janssen Research and Development LLC, Raritan, NJ, USA.
Moechars D; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Mercken M; Reference Center for Biological Markers of Dementia (BIODEM), Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
Van Nueten L; Department of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, Antwerp, Belgium.
Tritsmans L; Janssen Research and Development, A Division of Janssen Pharmaceutica N.V., Beerse, Belgium.
de Strooper B; Janssen Research and Development, A Division of Janssen Pharmaceutica N.V., Beerse, Belgium.
Streffer JR; Janssen Research and Development, A Division of Janssen Pharmaceutica N.V., Beerse, Belgium.

J Alzheimers Dis ; 56(4): 1437-1449, 2017.

Article en En | MEDLINE | ID: mdl-28157093

Asunto(s)

Secretasas de la Proteína Precursora del Amiloide/antagonistas & inhibidores; Secretasas de la Proteína Precursora del Amiloide/metabolismo; Péptidos beta-Amiloides/líquido cefalorraquídeo; Ácido Aspártico Endopeptidasas/antagonistas & inhibidores; Ácido Aspártico Endopeptidasas/metabolismo; Inhibidores de Proteasas/uso terapéutico; Proteínas tau/líquido cefalorraquídeo; Anciano; Enfermedad de Alzheimer/líquido cefalorraquídeo; Apolipoproteína E4/genética; Biomarcadores/líquido cefalorraquídeo; Método Doble Ciego; Femenino; Estudios de Seguimiento; Humanos; Masculino; Persona de Mediana Edad; Fosforilación/efectos de los fármacos; Inhibidores de Proteasas/efectos adversos; Inhibidores de Proteasas/farmacocinética

Palabras clave

AD markers; Alzheimer's disease; BACE-1; JNJ-54861911; ß-secretase enzyme

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Inhibidores de Proteasas / Péptidos beta-Amiloides / Ácido Aspártico Endopeptidasas / Proteínas tau / Secretasas de la Proteína Precursora del Amiloide Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Alzheimers Dis Asunto de la revista: GERIATRIA / NEUROLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Bélgica

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