Osteopontin splice variants and polymorphisms in cancer progression and prognosis.
Biochim Biophys Acta Rev Cancer
; 1868(1): 93-108.A, 2017 Aug.
Article
en En
| MEDLINE
| ID: mdl-28254527
ABSTRACT
Osteopontin (OPN) is an extracellular matrix protein that is overexpressed in various cancers and promotes oncogenic features including cell proliferation, survival, migration, and angiogenesis, among others. OPN can participate in the regulation of the tumor microenvironment, affecting both cancer and neighboring cells. Here, we review the roles of OPN splice variants (a, b, c) in cancer development, progression, and prognosis, and also discuss the identities of isoforms 4 and 5. We also discussed how single-nucleotide polymorphisms (SNPs) of the OPN gene are an additional factor influencing the level of OPN in individuals, modulating the risks of cancer development and outcome.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Polimorfismo Genético
/
Empalme del ARN
/
Osteopontina
/
Neoplasias
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Biochim Biophys Acta Rev Cancer
Año:
2017
Tipo del documento:
Article
País de afiliación:
Reino Unido