Gene body DNA methylation in plants.
Curr Opin Plant Biol
; 36: 103-110, 2017 04.
Article
en En
| MEDLINE
| ID: mdl-28258985
ABSTRACT
The type, amount, and location of DNA methylation within a gene provides pivotal information on the enzymatic pathway by which it was achieved and its functional consequences. In plants (angiosperms specifically), gene body methylation (gbM) refers to genes with an enrichment of CG DNA methylation within the transcribed regions and depletion at the transcriptional start and termination sites. GbM genes often compose the bulk of methylated genes within angiosperm genomes and are enriched for housekeeping functions. Contrary to the transcriptionally repressive effects of other chromatin modifications within gene bodies, gbM genes are constitutively expressed. GbM has intrigued researchers since its discovery, and much effort has been placed on identifying its functional role. Here, we highlight the recent findings on the evolutionary origin and molecular mechanism of gbM and synthesize studies describing the possible roles for this enigmatic epigenetic phenotype.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Genes de Plantas
/
Metilación de ADN
/
Magnoliopsida
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Curr Opin Plant Biol
Asunto de la revista:
BOTANICA
Año:
2017
Tipo del documento:
Article
País de afiliación:
Estados Unidos