Social network architecture of human immune cells unveiled by quantitative proteomics.
Nat Immunol
; 18(5): 583-593, 2017 05.
Article
en En
| MEDLINE
| ID: mdl-28263321
ABSTRACT
The immune system is unique in its dynamic interplay between numerous cell types. However, a system-wide view of how immune cells communicate to protect against disease has not yet been established. We applied high-resolution mass-spectrometry-based proteomics to characterize 28 primary human hematopoietic cell populations in steady and activated states at a depth of >10,000 proteins in total. Protein copy numbers revealed a specialization of immune cells for ligand and receptor expression, thereby connecting distinct immune functions. By integrating total and secreted proteomes, we discovered fundamental intercellular communication structures and previously unknown connections between cell types. Our publicly accessible (http//www.immprot.org/) proteomic resource provides a framework for the orchestration of cellular interplay and a reference for altered communication associated with pathology.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Células Sanguíneas
/
Proteoma
/
Proteómica
/
Mapas de Interacción de Proteínas
/
Inmunidad Celular
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Nat Immunol
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2017
Tipo del documento:
Article
País de afiliación:
Alemania