Regulation of Mammalian Mitochondrial Gene Expression: Recent Advances.
Trends Biochem Sci
; 42(8): 625-639, 2017 08.
Article
en En
| MEDLINE
| ID: mdl-28285835
ABSTRACT
Perturbation of mitochondrial DNA (mtDNA) gene expression can lead to human pathologies. Therefore, a greater appreciation of the basic mechanisms of mitochondrial gene expression is desirable to understand the pathophysiology of associated disorders. Although the purpose of the mitochondrial gene expression machinery is to provide only 13 proteins of the oxidative phosphorylation (OxPhos) system, recent studies have revealed its remarkable and unexpected complexity. We review here the latest breakthroughs in our understanding of the post-transcriptional processes of mitochondrial gene expression, focusing on advances in analyzing the mitochondrial epitranscriptome, the role of mitochondrial RNA granules (MRGs), the benefits of recently obtained structures of the mitochondrial ribosome, and the coordination of mitochondrial and cytosolic translation to orchestrate the biogenesis of OxPhos complexes.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Fosforilación Oxidativa
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Regulación de la Expresión Génica
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Genes Mitocondriales
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Ribosomas Mitocondriales
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Mitocondrias
Límite:
Animals
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Humans
Idioma:
En
Revista:
Trends Biochem Sci
Año:
2017
Tipo del documento:
Article
País de afiliación:
Reino Unido