Optimisation of the dibromomaleimide (DBM) platform for native antibody conjugation by accelerated post-conjugation hydrolysis.

Morais, Maurício; Nunes, João P M; Karu, Kersti; Forte, Nafsika; Benni, Irene; Smith, Mark E B; Caddick, Stephen; Chudasama, Vijay; Baker, James R

Morais, Maurício; Nunes, João P M; Karu, Kersti; Forte, Nafsika; Benni, Irene; Smith, Mark E B; Caddick, Stephen; Chudasama, Vijay; Baker, James R.

Afiliación

Morais M; Department of Chemistry, UCL, 20 Gordon St, London, UK WC1H 0AJ. j.r.baker@ucl.ac.uk v.chudasama@ucl.ac.uk.
Nunes JPM; Department of Chemistry, UCL, 20 Gordon St, London, UK WC1H 0AJ. j.r.baker@ucl.ac.uk v.chudasama@ucl.ac.uk.
Karu K; Department of Chemistry, UCL, 20 Gordon St, London, UK WC1H 0AJ. j.r.baker@ucl.ac.uk v.chudasama@ucl.ac.uk.
Forte N; Department of Chemistry, UCL, 20 Gordon St, London, UK WC1H 0AJ. j.r.baker@ucl.ac.uk v.chudasama@ucl.ac.uk.
Benni I; Department of Chemistry, UCL, 20 Gordon St, London, UK WC1H 0AJ. j.r.baker@ucl.ac.uk v.chudasama@ucl.ac.uk.
Smith MEB; Department of Chemistry, UCL, 20 Gordon St, London, UK WC1H 0AJ. j.r.baker@ucl.ac.uk v.chudasama@ucl.ac.uk.
Caddick S; Department of Chemistry, UCL, 20 Gordon St, London, UK WC1H 0AJ. j.r.baker@ucl.ac.uk v.chudasama@ucl.ac.uk.
Chudasama V; Department of Chemistry, UCL, 20 Gordon St, London, UK WC1H 0AJ. j.r.baker@ucl.ac.uk v.chudasama@ucl.ac.uk.
Baker JR; Department of Chemistry, UCL, 20 Gordon St, London, UK WC1H 0AJ. j.r.baker@ucl.ac.uk v.chudasama@ucl.ac.uk.

Org Biomol Chem ; 15(14): 2947-2952, 2017 Apr 05.

Article en En | MEDLINE | ID: mdl-28290574

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Texto completo: 1 Bases de datos: MEDLINE Idioma: En Revista: Org Biomol Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2017 Tipo del documento: Article