Amplified selectivity in cognitive processing implements the neural gain model of norepinephrine function.

ABSTRACT

Previous work has suggested that an interaction between local selective (e.g., glutamatergic) excitation and global gain modulation (via norepinephrine) amplifies selectivity in information processing. Mather et al. extend this existing theory by suggesting that localized gain modulation may further mediate this effect - an interesting prospect that invites new theoretical and experimental work.