Mutagenesis of Dengue Virus Protein NS2A Revealed a Novel Domain Responsible for Virus-Induced Cytopathic Effect and Interactions between NS2A and NS2B Transmembrane Segments.

Wu, Ren-Huang; Tsai, Ming-Han; Tsai, Kuen-Nan; Tian, Jia Ni; Wu, Jian-Sung; Wu, Su-Ying; Chern, Jyh-Haur; Chen, Chun-Hong; Yueh, Andrew

Wu, Ren-Huang; Tsai, Ming-Han; Tsai, Kuen-Nan; Tian, Jia Ni; Wu, Jian-Sung; Wu, Su-Ying; Chern, Jyh-Haur; Chen, Chun-Hong; Yueh, Andrew.

Afiliación

Wu RH; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli, Taiwan, Republic of China.
Tsai MH; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli, Taiwan, Republic of China.
Tsai KN; Institute of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli, Taiwan, Republic of China.
Tian JN; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli, Taiwan, Republic of China.
Wu JS; Department of Life Sciences, National Central University, Jhongli, Taiwan, Republic of China.
Wu SY; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli, Taiwan, Republic of China.
Chern JH; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli, Taiwan, Republic of China.
Chen CH; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli, Taiwan, Republic of China.
Yueh A; Institute of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli, Taiwan, Republic of China chunhong@nhri.org.tw andrewyueh@nhri.org.tw.

J Virol ; 91(12)2017 06 15.

Article en En | MEDLINE | ID: mdl-28381578

Asunto(s)

Efecto Citopatogénico Viral; Virus del Dengue/genética; Mutagénesis; Proteínas no Estructurales Virales/genética; Proteínas no Estructurales Virales/metabolismo; Alanina/metabolismo; Sustitución de Aminoácidos; Proliferación Celular/genética; Virus del Dengue/química; Virus del Dengue/fisiología; Células HEK293; Humanos; L-Lactato Deshidrogenasa/metabolismo; Leucina/genética; Mutación; Fenilalanina/genética; ARN Viral/metabolismo; Análisis de Secuencia; Proteínas no Estructurales Virales/química; Ensamble de Virus; Replicación Viral/genética

Palabras clave

RNA replication; cytopathic effect; dengue virus; intermolecular interaction; scanning mutagenesis; transmembrane segment

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Mutagénesis / Proteínas no Estructurales Virales / Efecto Citopatogénico Viral / Virus del Dengue Límite: Humans Idioma: En Revista: J Virol Año: 2017 Tipo del documento: Article País de afiliación: China

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