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PIK3CA mutant tumors depend on oxoglutarate dehydrogenase.
Ilic, Nina; Birsoy, Kivanç; Aguirre, Andrew J; Kory, Nora; Pacold, Michael E; Singh, Shambhavi; Moody, Susan E; DeAngelo, Joseph D; Spardy, Nicole A; Freinkman, Elizaveta; Weir, Barbara A; Tsherniak, Aviad; Cowley, Glenn S; Root, David E; Asara, John M; Vazquez, Francisca; Widlund, Hans R; Sabatini, David M; Hahn, William C.
Afiliación
  • Ilic N; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215.
  • Birsoy K; Broad Institute of MIT and Harvard University, Cambridge, MA 02142.
  • Aguirre AJ; Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY 10065.
  • Kory N; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215.
  • Pacold ME; Broad Institute of MIT and Harvard University, Cambridge, MA 02142.
  • Singh S; Broad Institute of MIT and Harvard University, Cambridge, MA 02142.
  • Moody SE; Whitehead Institute for Biomedical Research, Cambridge, MA 02142.
  • DeAngelo JD; David H. Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139.
  • Spardy NA; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Freinkman E; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Weir BA; Broad Institute of MIT and Harvard University, Cambridge, MA 02142.
  • Tsherniak A; Whitehead Institute for Biomedical Research, Cambridge, MA 02142.
  • Cowley GS; David H. Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139.
  • Root DE; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Asara JM; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Vazquez F; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215.
  • Widlund HR; Broad Institute of MIT and Harvard University, Cambridge, MA 02142.
  • Sabatini DM; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215.
  • Hahn WC; Broad Institute of MIT and Harvard University, Cambridge, MA 02142.
Proc Natl Acad Sci U S A ; 114(17): E3434-E3443, 2017 04 25.
Article en En | MEDLINE | ID: mdl-28396387
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Fosfatidilinositol 3-Quinasa Clase I / Complejo Cetoglutarato Deshidrogenasa / Mutación / Proteínas de Neoplasias / Neoplasias Límite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2017 Tipo del documento: Article
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Fosfatidilinositol 3-Quinasa Clase I / Complejo Cetoglutarato Deshidrogenasa / Mutación / Proteínas de Neoplasias / Neoplasias Límite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2017 Tipo del documento: Article