A functional screening of the kinome identifies the Polo-like kinase 4 as a potential therapeutic target for malignant rhabdoid tumors, and possibly, other embryonal tumors of the brain.

Sredni, Simone Treiger; Suzuki, Mario; Yang, Jian-Ping; Topczewski, Jacek; Bailey, Anders W; Gokirmak, Tufan; Gross, Jeffrey N; de Andrade, Alexandre; Kondo, Akihide; Piper, David R; Tomita, Tadanori

Sredni, Simone Treiger; Suzuki, Mario; Yang, Jian-Ping; Topczewski, Jacek; Bailey, Anders W; Gokirmak, Tufan; Gross, Jeffrey N; de Andrade, Alexandre; Kondo, Akihide; Piper, David R; Tomita, Tadanori.

Afiliación

Sredni ST; Division of Pediatric Neurosurgery, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.
Suzuki M; Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Yang JP; Department of Cancer Biology and Epigenomics, Stanley Manne Children's Research Institute, Chicago, Illinois.
Topczewski J; Division of Pediatric Neurosurgery, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.
Bailey AW; Department of Cancer Biology and Epigenomics, Stanley Manne Children's Research Institute, Chicago, Illinois.
Gokirmak T; Department of Neurosurgery, School of Medicine, Juntendo University, Tokyo, Japan.
Gross JN; Research and Development, Biosciences Division, Thermo Fisher Scientific, Carlsbad, California.
de Andrade A; Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Kondo A; Department of Developmental Biology, Stanley Manne Children's Research Institute, Chicago, Illinois.
Piper DR; Division of Pediatric Neurosurgery, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.
Tomita T; Department of Cancer Biology and Epigenomics, Stanley Manne Children's Research Institute, Chicago, Illinois.

Pediatr Blood Cancer ; 64(11)2017 Nov.

Article en En | MEDLINE | ID: mdl-28398638

Asunto(s)

Neoplasias Encefálicas/tratamiento farmacológico; Sistemas CRISPR-Cas/genética; Ensayos Analíticos de Alto Rendimiento/métodos; Indazoles/farmacología; Indoles/farmacología; Proteínas Serina-Treonina Quinasas/metabolismo; Tumor Rabdoide/tratamiento farmacológico; Secuencia de Aminoácidos; Animales; Neoplasias Encefálicas/genética; Neoplasias Encefálicas/patología; Ciclo Celular/efectos de los fármacos; Proliferación Celular/efectos de los fármacos; Humanos; Larva/crecimiento & desarrollo; Larva/metabolismo; Mutación/genética; Proteínas Serina-Treonina Quinasas/antagonistas & inhibidores; Proteínas Serina-Treonina Quinasas/genética; Tumor Rabdoide/genética; Tumor Rabdoide/patología; Alineación de Secuencia; Células Tumorales Cultivadas; Pez Cebra/crecimiento & desarrollo; Pez Cebra/metabolismo

Palabras clave

AT/RT; CFI-400495; CRISPR/Cas9; Lentivirus; MRT; PLK4; PLK4i; RTK; gene editing; inhibitor; kinase; kinome; rhabdoid; treatment

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Proteínas Serina-Treonina Quinasas / Tumor Rabdoide / Ensayos Analíticos de Alto Rendimiento / Sistemas CRISPR-Cas / Indazoles / Indoles Tipo de estudio: Diagnostic_studies / Prognostic_studies / Screening_studies Límite: Animals / Humans Idioma: En Revista: Pediatr Blood Cancer Asunto de la revista: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Año: 2017 Tipo del documento: Article

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