Cordycepin confers neuroprotection in mice models of intracerebral hemorrhage via suppressing NLRP3 inflammasome activation.

Cheng, Yijun; Wei, Yongxu; Yang, Wenlei; Song, Yaying; Shang, Hanbing; Cai, Yu; Wu, Zhebao; Zhao, Weiguo

Cheng, Yijun; Wei, Yongxu; Yang, Wenlei; Song, Yaying; Shang, Hanbing; Cai, Yu; Wu, Zhebao; Zhao, Weiguo.

Afiliación

Cheng Y; Department of Neurosurgery, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People's Republic of China.
Wei Y; Department of Neurosurgery, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People's Republic of China.
Yang W; Department of Neurosurgery, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People's Republic of China.
Song Y; Department of Neurology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People's Republic of China.
Shang H; Department of Neurosurgery, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People's Republic of China.
Cai Y; Department of Neurosurgery, North Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201800, People's Republic of China. caiyu10746@sina.com.
Wu Z; Department of Neurosurgery, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People's Republic of China. wuzhebao@aliyun.com.
Zhao W; Department of Neurosurgery, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People's Republic of China. ruijinsjwk@qq.com.

Metab Brain Dis ; 32(4): 1133-1145, 2017 08.

Article en En | MEDLINE | ID: mdl-28401330

Asunto(s)

Edema Encefálico/tratamiento farmacológico; Hemorragia Cerebral/tratamiento farmacológico; Desoxiadenosinas/uso terapéutico; Inflamasomas/efectos de los fármacos; Proteína con Dominio Pirina 3 de la Familia NLR/metabolismo; Fármacos Neuroprotectores/uso terapéutico; Animales; Edema Encefálico/metabolismo; Muerte Celular/efectos de los fármacos; Hemorragia Cerebral/metabolismo; Desoxiadenosinas/farmacología; Modelos Animales de Enfermedad; Inflamasomas/metabolismo; Masculino; Ratones; Ratones Endogámicos ICR; Neuronas/efectos de los fármacos; Neuronas/metabolismo; Fármacos Neuroprotectores/farmacología

Palabras clave

Cordycepin; HMGB1; Intracerebral hemorrhage; NLRP3 inflammasome; Neuroinflammation; Neuronal death

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Edema Encefálico / Hemorragia Cerebral / Desoxiadenosinas / Fármacos Neuroprotectores / Inflamasomas / Proteína con Dominio Pirina 3 de la Familia NLR Límite: Animals Idioma: En Revista: Metab Brain Dis Asunto de la revista: CEREBRO / METABOLISMO Año: 2017 Tipo del documento: Article

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