Templated Self-Assembly of a Covalent Polymer Network for Intracellular Protein Delivery and Traceless Release.
J Am Chem Soc
; 139(16): 5676-5679, 2017 04 26.
Article
en En
| MEDLINE
| ID: mdl-28406017
ABSTRACT
Trafficking proteins inside cells is an emerging field with potential utility in basic cell biology and biological therapeutics. A robust and sustainable delivery strategy demands not only good protection of the cargo but also reversibility in conjugation and activity. We report a protein-templated polymer self-assembly strategy for forming a sheath around the proteins and then tracelessly releasing them in the cytosol. The versatility of the approach, demonstrated here, suggests that the strategy is compatible with a wide array of biologics.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Polímeros
/
Proteínas
/
Citosol
Límite:
Humans
Idioma:
En
Revista:
J Am Chem Soc
Año:
2017
Tipo del documento:
Article
País de afiliación:
Estados Unidos