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Probing the lithium-response pathway in hiPSCs implicates the phosphoregulatory set-point for a cytoskeletal modulator in bipolar pathogenesis.
Tobe, Brian T D; Crain, Andrew M; Winquist, Alicia M; Calabrese, Barbara; Makihara, Hiroko; Zhao, Wen-Ning; Lalonde, Jasmin; Nakamura, Haruko; Konopaske, Glenn; Sidor, Michelle; Pernia, Cameron D; Yamashita, Naoya; Wada, Moyuka; Inoue, Yuuka; Nakamura, Fumio; Sheridan, Steven D; Logan, Ryan W; Brandel, Michael; Wu, Dongmei; Hunsberger, Joshua; Dorsett, Laurel; Duerr, Cordulla; Basa, Ranor C B; McCarthy, Michael J; Udeshi, Namrata D; Mertins, Philipp; Carr, Steven A; Rouleau, Guy A; Mastrangelo, Lina; Li, Jianxue; Gutierrez, Gustavo J; Brill, Laurence M; Venizelos, Nikolaos; Chen, Guang; Nye, Jeffrey S; Manji, Husseini; Price, Jeffrey H; McClung, Colleen A; Akiskal, Hagop S; Alda, Martin; Chuang, De-Maw M; Coyle, Joseph T; Liu, Yang; Teng, Yang D; Ohshima, Toshio; Mikoshiba, Katsuhiko; Sidman, Richard L; Halpain, Shelley; Haggarty, Stephen J; Goshima, Yoshio.
Afiliación
  • Tobe BTD; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037.
  • Crain AM; Sanford Consortium for Regenerative Medicine, La Jolla, CA 92037.
  • Winquist AM; Department of Psychiatry, Veterans Administration Medical Center, La Jolla, CA 92037.
  • Calabrese B; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037.
  • Makihara H; Sanford Consortium for Regenerative Medicine, La Jolla, CA 92037.
  • Zhao WN; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037.
  • Lalonde J; Sanford Consortium for Regenerative Medicine, La Jolla, CA 92037.
  • Nakamura H; Sanford Consortium for Regenerative Medicine, La Jolla, CA 92037.
  • Konopaske G; Section of Neurobiology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92037.
  • Sidor M; Department of Molecular Pharmacology & Neurobiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
  • Pernia CD; Chemical Neurobiology Laboratory, Center for Genomic Medicine, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.
  • Yamashita N; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.
  • Wada M; Chemical Neurobiology Laboratory, Center for Genomic Medicine, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.
  • Inoue Y; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.
  • Nakamura F; Department of Molecular Pharmacology & Neurobiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
  • Sheridan SD; Mailman Research Center, McLean Hospital, Belmont, MA 02478.
  • Logan RW; Department of Psychiatry, Harvard Medical School, Boston, MA 02115.
  • Brandel M; Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030.
  • Wu D; Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA 15219.
  • Hunsberger J; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037.
  • Dorsett L; Sanford Consortium for Regenerative Medicine, La Jolla, CA 92037.
  • Duerr C; Department of Molecular Pharmacology & Neurobiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
  • Basa RCB; Department of Molecular Pharmacology & Neurobiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
  • McCarthy MJ; Department of Molecular Pharmacology & Neurobiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
  • Udeshi ND; Department of Molecular Pharmacology & Neurobiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
  • Mertins P; Chemical Neurobiology Laboratory, Center for Genomic Medicine, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.
  • Carr SA; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.
  • Rouleau GA; Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA 15219.
  • Mastrangelo L; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037.
  • Li J; Sanford Consortium for Regenerative Medicine, La Jolla, CA 92037.
  • Gutierrez GJ; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037.
  • Brill LM; Molecular Neurobiology Section, National Institute of Mental Health, Bethesda, MD 20892-1363.
  • Venizelos N; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037.
  • Chen G; Sanford Consortium for Regenerative Medicine, La Jolla, CA 92037.
  • Nye JS; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037.
  • Manji H; Sanford Consortium for Regenerative Medicine, La Jolla, CA 92037.
  • Price JH; Vala Sciences, Inc., San Diego, CA 92121.
  • McClung CA; Department of Psychiatry, Veterans Administration Medical Center, La Jolla, CA 92037.
  • Akiskal HS; Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093-0737.
  • Alda M; Broad Institute of MIT and Harvard University, Cambridge, MA 02142.
  • Chuang DM; Broad Institute of MIT and Harvard University, Cambridge, MA 02142.
  • Coyle JT; Broad Institute of MIT and Harvard University, Cambridge, MA 02142.
  • Liu Y; Department of Psychiatry, Dalhousie University, Halifax, NS, Canada B3H 2E2.
  • Teng YD; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037.
  • Ohshima T; Sanford Consortium for Regenerative Medicine, La Jolla, CA 92037.
  • Mikoshiba K; Department of Neurology, Beth Israel-Deaconess Medical Center, Boston, MA 02215.
  • Sidman RL; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037.
  • Halpain S; Department of Biology, Vrije Universiteit Brussels, 1050 Brussels, Belgium.
  • Haggarty SJ; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037.
  • Goshima Y; Department of Cinical Medicine, Örebro University, Örebro SE-701 82, Sweden.
Proc Natl Acad Sci U S A ; 114(22): E4462-E4471, 2017 05 30.
Article en En | MEDLINE | ID: mdl-28500272
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Trastorno Bipolar / Procesamiento Proteico-Postraduccional / Células Madre Pluripotentes Inducidas / Litio / Modelos Biológicos Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2017 Tipo del documento: Article
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Trastorno Bipolar / Procesamiento Proteico-Postraduccional / Células Madre Pluripotentes Inducidas / Litio / Modelos Biológicos Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2017 Tipo del documento: Article