Resistance to malaria through structural variation of red blood cell invasion receptors.
Science
; 356(6343)2017 06 16.
Article
en En
| MEDLINE
| ID: mdl-28522690
ABSTRACT
The malaria parasite Plasmodium falciparum invades human red blood cells by a series of interactions between host and parasite surface proteins. By analyzing genome sequence data from human populations, including 1269 individuals from sub-Saharan Africa, we identify a diverse array of large copy-number variants affecting the host invasion receptor genes GYPA and GYPB We find that a nearby association with severe malaria is explained by a complex structural rearrangement involving the loss of GYPB and gain of two GYPB-A hybrid genes, which encode a serologically distinct blood group antigen known as Dantu. This variant reduces the risk of severe malaria by 40% and has recently increased in frequency in parts of Kenya, yet it appears to be absent from west Africa. These findings link structural variation of red blood cell invasion receptors with natural resistance to severe malaria.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Glicoforinas
/
Modelos Moleculares
/
Malaria Falciparum
/
Eritrocitos
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Resistencia a la Enfermedad
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Interacciones Huésped-Parásitos
Tipo de estudio:
Prognostic_studies
Límite:
Adult
/
Child
/
Humans
País/Región como asunto:
Africa
Idioma:
En
Revista:
Science
Año:
2017
Tipo del documento:
Article
País de afiliación:
Reino Unido