Hh signaling in regeneration of the ischemic heart.
Cell Mol Life Sci
; 74(19): 3481-3490, 2017 10.
Article
en En
| MEDLINE
| ID: mdl-28523343
ABSTRACT
Myocardial infarction (MI) is caused by the occlusion of a coronary artery due to underlying atherosclerosis complicated by localized thrombosis. The blockage of blood flow leads to cardiomyocyte (CM) death in the infarcted area. Adult mammalian cardiomyocytes have little capacity to proliferate in response to injury; however, some pathways active during embryogenesis and silent during adult life are recruited in response to tissue injury. One such example is hedgehog (Hh) signaling. Hh is involved in the embryonic development of the heart and coronary vascular system. Pathological conditions including ischemia activate Hh signaling in adult tissues. This review highlights the involvement of Hh signaling in ischemic tissue regeneration with a particular emphasis on heart regeneration and discusses its potential role as a therapeutic agent.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Regeneración
/
Transducción de Señal
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Isquemia Miocárdica
/
Proteínas Hedgehog
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Corazón
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Cell Mol Life Sci
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2017
Tipo del documento:
Article
País de afiliación:
Países Bajos