AcetylacetonateBODIPY-Biscyclometalated Iridium(III) Complexes: Effective Strategy towards Smarter Fluorescent Photosensitizer Agents.
Chemistry
; 23(42): 10139-10147, 2017 Jul 26.
Article
en En
| MEDLINE
| ID: mdl-28543812
ABSTRACT
Biscyclometalated IrIII complexes involving boron-dipyrromethene (BODIPY)-based ancillary ligands, where the BODIPY unit is grafted to different chelating cores (acetylacetonate for Ir-1 and Ir-2, and bipyridine for Ir-3) by the BODIPY meso position, have been synthesized and characterized. Complexes with the BODIPY moiety directly grafted to acetylacetonate (Ir-1 and Ir-2) exhibit higher absorption coefficients (ϵ≈4.46×104 m-1 cm-1 and 3.38×104 m-1 â
cm-1 at 517â
nm and 594â
nm, respectively), higher moderate fluorescence emission (φfl ≈0.08 and 0.22 at 528â
nm and 652â
nm, respectively) and, in particular, more efficient singlet oxygen generation upon visible-light irradiation (φΔ ≈0.86 and 0.59, respectively) than that exhibited by Ir-3 (φΔ ≈0.51, but only under UV light). Phosphorescence emission, nanosecond time-resolved transient absorption, and DFT calculations suggest that BODIPY-localized long-lived 3 IL states are populated for Ir-1 and Ir-2. In vitro photodynamic therapy (PDT) activity studied for Ir-1 and Ir-2 in HeLa cells shows that such complexes are efficiently internalized into the cells, exhibiting low dark- and high photocytoxicity, even at significantly low complex concentration, making them potentially suitable as theranostic agents.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Compuestos de Boro
/
Fármacos Fotosensibilizantes
/
Complejos de Coordinación
/
Iridio
Límite:
Humans
Idioma:
En
Revista:
Chemistry
Asunto de la revista:
QUIMICA
Año:
2017
Tipo del documento:
Article
País de afiliación:
España